PREX1 and IPO13

Data Source:
BioGRID (proximity labelling technology)

		PREX1	IPO13
Description		phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	importin 13
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Dendritic Shaft Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Phospholipid Binding Enzyme Binding	Protein Binding
	Biological Process	Superoxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Actin Filament Polymerization T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Neutrophil Activation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Dendrite Development Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Protein Import Into Nucleus
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Colorectal cancer ( 30529582 26151821 31826910) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Diastolic blood pressure ( 28135244 27841878 27618447) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Multiple myeloma ( 27363682) Nephrotic syndrome (acquired) ( 21441931) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Tonometry ( 17903302) Waist circumference ( 28552196) White blood cell count ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		6 interacting genes: ITSN1 MTOR NCDN PPP1CA RAC1 RHOA	17 interacting genes: ALX1 CRX EIF1AX GK HMBOX1 MAGOH NPSR1 NUP50 PAX3 PAX6 PBX4 PITX1 PSMA1 RAN RBM8A RPL5 UBE2I
Entrez ID		57580	9670
HPRD ID		06066	13742
Ensembl ID		ENSG00000124126	ENSG00000117408
Uniprot IDs		Q8TCU6	O94829
PDB IDs		3QIK 4YON 5D27 5D3V 5D3W 5D3X 5D3Y 5FI0 5FI1 6PCV 6VSK	2X19 2XWU 3ZJY
Enriched GO Terms of Interacting Partners?
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