SEMA6A and SORBS2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SEMA6A	SORBS2
Description		semaphorin 6A	sorbin and SH3 domain containing 2
Image
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Integral Component Of Membrane Axon	Nucleus Plasma Membrane Focal Adhesion Actin Cytoskeleton Apical Plasma Membrane Z Disc Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Structural Constituent Of Muscle
	Biological Process	Neural Crest Cell Migration Apoptotic Process Cytoskeleton Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Animal Organ Morphogenesis Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Negative Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Negative Regulation Of Cell Adhesion Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Neuron Migration	Actin Filament Organization Notch Signaling Pathway Biological_process Cell Growth Involved In Cardiac Muscle Cell Development
Pathways		Other semaphorin interactions
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096) Amyotrophic lateral sclerosis ( 19451621) Blood protein levels ( 29875488) Body mass index ( 27296613) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Eosinophilic esophagitis ( 25017104) High chromosomal aberration frequency (chromatid type) ( 31586183) Periodontitis (DPAL) ( 24024966) Subcortical volume (MOSTest) ( 32665545) Wegener's granulomatosis ( 23740775)	Cardiac Troponin-T levels ( 31014085) Coronary artery disease ( 33020668) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) Short-term memory (digit-span task) ( 30741946) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		6 interacting genes: EVL ITSN2 SH3RF1 SORBS1 SORBS2 UBE2I	45 interacting genes: ABI1 ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL CBLB DLGAP1 DLGAP2 DLGAP4 EFS EGFR EIF3H FAT1 FLOT1 GOLGA2 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SH3RF1 SOCS7 SYNJ1 TEPSIN TRAF4 VCL VPS37C WAS WASF1 WASL YWHAE YWHAZ
Entrez ID		57556	8470
HPRD ID		06906	12473
Ensembl ID		ENSG00000092421	ENSG00000154556
Uniprot IDs		A0A0A0MQU6 Q9H2E6	B7Z3D7 B7Z997 O94875
PDB IDs		6WTS	5VEI
Enriched GO Terms of Interacting Partners?
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