SEMA6A and SORBS1

Data Source:
HPRD (two hybrid)

		SEMA6A	SORBS1
Description		semaphorin 6A	sorbin and SH3 domain containing 1
Image
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Integral Component Of Membrane Axon	Stress Fiber Nucleus Centrosome Cytosol Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Nuclear Matrix Cell-substrate Junction Membrane Raft
	Molecular Function	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Neural Crest Cell Migration Apoptotic Process Cytoskeleton Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Animal Organ Morphogenesis Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Negative Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Negative Regulation Of Cell Adhesion Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Neuron Migration	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Other semaphorin interactions	Smooth Muscle Contraction
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096) Amyotrophic lateral sclerosis ( 19451621) Blood protein levels ( 29875488) Body mass index ( 27296613) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Eosinophilic esophagitis ( 25017104) High chromosomal aberration frequency (chromatid type) ( 31586183) Periodontitis (DPAL) ( 24024966) Subcortical volume (MOSTest) ( 32665545) Wegener's granulomatosis ( 23740775)	Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)
Interacting Genes		6 interacting genes: EVL ITSN2 SH3RF1 SORBS1 SORBS2 UBE2I	27 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL
Entrez ID		57556	10580
HPRD ID		06906	05587
Ensembl ID		ENSG00000092421	ENSG00000095637
Uniprot IDs		A0A0A0MQU6 Q9H2E6	B4DTX5 Q9BX66
PDB IDs		6WTS	2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP
Enriched GO Terms of Interacting Partners?
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