SORBS1 and FLOT1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SORBS1	FLOT1
Description		sorbin and SH3 domain containing 1	flotillin 1
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Centrosome Cytosol Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Nuclear Matrix Cell-substrate Junction Membrane Raft	Uropod Lysosomal Membrane Endosome Early Endosome Microtubule Organizing Center Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion COP9 Signalosome External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Cortical Actin Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Melanosome Cell-cell Contact Zone Membrane Raft Presynaptic Active Zone Extracellular Exosome Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Membrane Raft Assembly Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Axonogenesis Extracellular Matrix Disassembly Positive Regulation Of Protein Binding Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Interferon-beta Production DsRNA Transport Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Rho Protein Signal Transduction Plasma Membrane Raft Assembly Positive Regulation Of Endocytosis Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Neurotransmitter Uptake Positive Regulation Of Cell Adhesion Molecule Production Protein Kinase C Signaling Cellular Response To Exogenous DsRNA Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Cell Junction Assembly Protein Localization To Membrane Raft Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Smooth Muscle Contraction	RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules
Drugs
Diseases
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) General cognitive ability ( 29844566) Handedness (non-right-handed vs right-handed) ( 31504236) Schizophrenia ( 30285260) Sleep duration ( 25469926) Ulcerative colitis ( 20848476)
Interacting Genes		27 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL	23 interacting genes: APP ARG1 AURKB BANP CAPN10 CBL CCDC102B COX5B FAM90A1 FLOT2 FYN GOLM1 HGS INCENP NGB NME7 PSMD4 SHBG SORBS1 SORBS2 SORBS3 SRPK1 UBC
Entrez ID		10580	10211
HPRD ID		05587	06105
Ensembl ID		ENSG00000095637	ENSG00000137312
Uniprot IDs		B4DTX5 Q9BX66	O75955 Q5ST80
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP
Enriched GO Terms of Interacting Partners?
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