NLGN2 and DLG3

Data Source:
BioGRID (two hybrid)

		NLGN2	DLG3
Description		neuroligin 2	discs large MAGUK scaffold protein 3
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Inhibitory Synapse Spanning Component Of Membrane Glycinergic Synapse Dopaminergic Synapse Symmetric, GABA-ergic, Inhibitory Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane	Extracellular Space Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Basolateral Plasma Membrane Cell Junction
	Molecular Function	Signaling Receptor Activity Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding	Protein Binding Kinase Binding Phosphatase Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Sensory Perception Of Pain Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Synaptic Vesicle Endocytosis Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Terminal Button Organization Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Potential Cell-cell Adhesion Presynapse Assembly Positive Regulation Of Protein Localization To Synapse Inhibitory Synapse Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering	MAPK Cascade Negative Regulation Of Cell Population Proliferation Embryo Development Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of NMDA Receptor Activity
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Refractive error ( 32231278) Uterine fibroids ( 30194396)	Mean platelet volume ( 32888494)
Interacting Genes		8 interacting genes: DLG2 DLG3 DLG4 MDGA1 NRXN1 NRXN2 NRXN3 PATJ	48 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OSBP2 PLEKHA2 PTK2B RPS8 SCN4A SCN5A SEMA4C SYNGAP1 VTN
Entrez ID		57555	1741
HPRD ID		07348	02177
Ensembl ID		ENSG00000169992	ENSG00000082458
Uniprot IDs		Q8NFZ4	Q59FY1 Q92796
PDB IDs		5XEQ	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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