CGN and F11R

Data Source:
HPRD (in vitro, in vivo)

		CGN	F11R
Description		cingulin	F11 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Myosin Complex Cell Junction	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Cell Junction Cytoplasmic Vesicle Protein-containing Complex Slit Diaphragm Extracellular Exosome Tight Junction
	Molecular Function	Motor Activity Actin Binding Protein Binding Cadherin Binding	Virus Receptor Activity Integrin Binding Protein Binding PDZ Domain Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Biological_process	Regulation Of Cytokine Production Inflammatory Response Leukocyte Cell-cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Shape Response To Radiation Extracellular Matrix Organization Actomyosin Structure Organization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of GTPase Activity Positive Regulation Of Rho Protein Signal Transduction Maintenance Of Blood-brain Barrier Memory T Cell Extravasation Positive Regulation Of GTPase Activity Positive Regulation Of Blood Pressure Viral Entry Into Host Cell Intestinal Absorption Leukocyte Migration Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Bicellular Tight Junction Assembly Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Positive Regulation Of Platelet Aggregation Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Actin Cytoskeleton Reorganization Regulation Of Bicellular Tight Junction Assembly
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	Cell surface interactions at the vascular wall Integrin cell surface interactions TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Inflammatory bowel disease ( 23128233) Night sleep phenotypes ( 27126917)
Interacting Genes		9 interacting genes: ARHGEF2 CDC42 F11R LNX1 PPP1R13B TJP1 TJP2 TP53BP2 YWHAG	30 interacting genes: AFDN ASIP BDNF CAMLG CASK CGN CSNK2A1 F2RL2 ITGAL JAGN1 MARCHF2 MMP14 MPDZ MYADM PARD3 PEX19 PGAP2 PICK1 PRKCA PTPRB RABAC1 SGTA SLC30A2 SLC35A1 SNAP47 STRIT1 TJP1 TMEM100 TMEM147 TMEM86B
Entrez ID		57530	50848
HPRD ID		10827	12038
Ensembl ID		ENSG00000143375	ENSG00000158769
Uniprot IDs		Q9P2M7	Q6FIB4 Q9Y624
PDB IDs			1NBQ 3EOY 3TSZ 4ODB
Enriched GO Terms of Interacting Partners?
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