CGN and TJP2

Data Source:
HPRD (in vitro, in vivo)

		CGN	TJP2
Description		cingulin	tight junction protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Myosin Complex Cell Junction	Nucleus Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Cell-cell Contact Zone
	Molecular Function	Motor Activity Actin Binding Protein Binding Cadherin Binding	Guanylate Kinase Activity Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Cadherin Binding Cell Adhesion Molecule Binding Protein Tyrosine Kinase Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Biological_process	Homotypic Cell-cell Adhesion Hippo Signaling Maintenance Of Blood-brain Barrier Cell-cell Junction Organization GMP Metabolic Process GDP Metabolic Process Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Protein Localization To Cell-cell Junction Positive Regulation Of Blood-brain Barrier Permeability
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	Signaling by Hippo Apoptotic cleavage of cell adhesion proteins
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Macular thickness ( 30535121) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 23396134 32231278) Renal sinus fat ( 22044751) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		9 interacting genes: ARHGEF2 CDC42 F11R LNX1 PPP1R13B TJP1 TJP2 TP53BP2 YWHAG	17 interacting genes: CDK6 CGN CLDN1 CLDN2 CLK1 CTNNA1 EPB41 HGS HSPB1 SAFB SCRIB SH3KBP1 SRPK2 TJP1 YWHAB YWHAG YWHAZ
Entrez ID		57530	9414
HPRD ID		10827	06369
Ensembl ID		ENSG00000143375	ENSG00000119139
Uniprot IDs		Q9P2M7	B7Z2R3 B7Z954 Q9UDY2
PDB IDs			2OSG 3E17
Enriched GO Terms of Interacting Partners?
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