RPTOR and WIPI2

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		RPTOR	WIPI2
Description		regulatory associated protein of MTOR complex 1	WD repeat domain, phosphoinositide interacting 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Dendrite TORC1 Complex Neuronal Cell Body	Phagophore Assembly Site Nucleoplasm Autophagosome Cytosol Membrane Extrinsic Component Of Membrane Protein-containing Complex Phagophore Assembly Site Membrane
	Molecular Function	RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Protein-containing Complex Binding 14-3-3 Protein Binding	Protein Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Cell Cycle Arrest Regulation Of Cell Size Cellular Response To Starvation Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Viral Process Regulation Of Macroautophagy Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Autophagosome Assembly Autophagy Of Mitochondrion Protein Lipidation Cellular Response To Starvation Macroautophagy Protein Localization To Phagophore Assembly Site Autophagy Of Nucleus Protein Lipidation Involved In Autophagosome Assembly Autophagosome Maturation Xenophagy
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Macroautophagy
Drugs
Diseases
GWAS		Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)	Bone mineral density x blood lead interaction in current smokers (1df test) ( 29518117) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Red blood cell count ( 32888494)
Interacting Genes		23 interacting genes: CILK1 DUXAP9 EIF4EBP1 EIF4EBP2 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NRBF2 PLD2 PRKAA1 PRKAA2 RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB WIPI2	16 interacting genes: ARL6IP1 COPS6 DDB1 DGAT2L6 FKBP7 MRRF MTOR OPTN POT1 RABAC1 REEP6 RPTOR STRN4 SYP TERF2IP UBE2L3
Entrez ID		57521	26100
HPRD ID		06184	15679
Ensembl ID		ENSG00000141564	ENSG00000157954
Uniprot IDs		Q6DKI0 Q8N122	A0A024R823 Q9Y4P8
PDB IDs		5H64 6BCU 6BCX 6SB0 6SB2 6U62
Enriched GO Terms of Interacting Partners?
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