RPTOR and MLST8

Data Source:
HPRD (in vivo)

		RPTOR	MLST8
Description		regulatory associated protein of MTOR complex 1	MTOR associated protein, LST8 homolog
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Dendrite TORC1 Complex Neuronal Cell Body	Nucleoplasm Cytoplasm Cytosol TORC1 Complex TORC2 Complex
	Molecular Function	RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Protein-containing Complex Binding 14-3-3 Protein Binding	Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Cell Cycle Arrest Regulation Of Cell Size Cellular Response To Starvation Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Viral Process Regulation Of Macroautophagy Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Cell Cycle Arrest Regulation Of Macroautophagy TOR Signaling Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Regulation Of Actin Cytoskeleton Organization TORC1 Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)	Height ( 28552196)
Interacting Genes		23 interacting genes: CILK1 DUXAP9 EIF4EBP1 EIF4EBP2 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NRBF2 PLD2 PRKAA1 PRKAA2 RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB WIPI2	7 interacting genes: A2M APPL2 ATXN1 EIF4EBP1 MTOR PRMT1 RPTOR
Entrez ID		57521	64223
HPRD ID		06184	17031
Ensembl ID		ENSG00000141564	ENSG00000167965
Uniprot IDs		Q6DKI0 Q8N122	Q9BVC4
PDB IDs		5H64 6BCU 6BCX 6SB0 6SB2 6U62	4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5H64 5WBU 5WBY 5ZCS 6BCU 6BCX 6SB0 6SB2
Enriched GO Terms of Interacting Partners?
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