COG6 and CUL5

Data Source:
BioGRID (two hybrid)

		COG6	CUL5
Description		component of oligomeric golgi complex 6	cullin 5
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Transport Complex Trans-Golgi Network Membrane	Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Protein Transport Glycosylation	G1/S Transition Of Mitotic Cell Cycle Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERBB2 Signaling Pathway Post-translational Protein Modification Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31959851 30929738 32296059) Asthma (adult onset) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 31562340) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Psoriasis ( 25903422 18369459) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Refractive error ( 32231278)
Interacting Genes		66 interacting genes: ARHGEF5 ATXN7 BAIAP2 BCL10 CCDC116 CCDC120 CCDC187 CCDC92 CCHCR1 CNN1 CNNM3 CSRP2 CUL5 DOCK8 DTNB FAM110A FAM90A1 FANCG FNDC11 GAS8 GEM GOLGA2 GRAP2 IGFN1 KANK2 LGALS14 LMO4 MCM7 MFAP1 MRI1 NDUFA5 NEK6 NTAQ1 NUP58 OAS1 PLEKHA2 POM121 PPP1R18 PPP1R32 PSMA1 PSMB1 QARS1 RAB3IL1 RAB6B RSPH14 RTP5 RUNX1T1 SCNM1 SMARCD1 SNAI1 SNAP29 SNRPB SPG21 SYCP2L SYT17 TBC1D22B TMSB4X TSGA10 TSHZ3 TSNAX TTC7B UFSP1 WASHC3 ZBTB16 ZFC3H1 ZNF417	36 interacting genes: ANAPC11 ASB11 CCNB1IP1 CCNDBP1 COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DEPTOR ELOA ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBC UBE2F VHL
Entrez ID		57511	8065
HPRD ID		08445	03444
Ensembl ID		ENSG00000133103	ENSG00000166266
Uniprot IDs		A0A024RDW5 A0A140VJG7 Q9Y2V7	Q93034
PDB IDs			3DPL 3DQV 4JGH 4N9F 6V9I
Enriched GO Terms of Interacting Partners?
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