SPC24 and WHRN

Data Source:
BioGRID (two hybrid)

		SPC24	WHRN
Description		SPC24 component of NDC80 kinetochore complex	whirlin
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GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleoplasm Nucleolus Cytosol Ndc80 Complex	Photoreceptor Inner Segment Stereocilia Ankle Link Stereocilia Ankle Link Complex Cytoplasm Actin Filament Plasma Membrane Growth Cone Photoreceptor Connecting Cilium Stereocilium Stereocilium Tip Ciliary Basal Body Neuronal Cell Body Synapse Periciliary Membrane Compartment USH2 Complex
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Cell Cycle Cell Division	Retina Homeostasis Sensory Perception Of Sound Positive Regulation Of Gene Expression Cerebellar Purkinje Cell Layer Formation Establishment Of Protein Localization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Sensory Perception Of Light Stimulus Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Stereocilium Organization Paranodal Junction Maintenance
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases			Usher syndrome (US) Deafness, autosomal recessive
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)
Interacting Genes		8 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SPC25 SUOX WHRN	17 interacting genes: BEND7 BMI1 CASK COL17A1 EFHC1 GOLGA2 GPSM2 HEMGN KEAP1 LRP4 LRRC4C MYO15A MYO7A PXN RPS6KA1 SPC24 TPRN
Entrez ID		147841	25861
HPRD ID		15464	09718
Ensembl ID		ENSG00000161888	ENSG00000095397
Uniprot IDs		B4E086 Q8NBT2	B9EGE6 Q9P202
PDB IDs		2VE7 3IZ0	1UEZ 1UF1 1UFX 6KZ1
Enriched GO Terms of Interacting Partners?
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