SPC24 and SKA3

Data Source:
BioGRID (two hybrid, two hybrid)

		SPC24	SKA3
Description		SPC24 component of NDC80 kinetochore complex	spindle and kinetochore associated complex subunit 3
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GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleoplasm Nucleolus Cytosol Ndc80 Complex	Kinetochore Condensed Chromosome Outer Kinetochore Centrosome Cytosol Spindle Microtubule Mitotic Spindle
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Cycle Cell Division	Mitotic Cell Cycle Chromosome Segregation Regulation Of Microtubule Polymerization Or Depolymerization Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)
Interacting Genes		8 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SPC25 SUOX WHRN	7 interacting genes: APP AURKB LRRK2 NOL4 SKA1 SPC24 ZDHHC17
Entrez ID		147841	221150
HPRD ID		15464	10706
Ensembl ID		ENSG00000161888	ENSG00000165480
Uniprot IDs		B4E086 Q8NBT2	Q8IX90
PDB IDs		2VE7 3IZ0	4AJ5
Enriched GO Terms of Interacting Partners?
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