DNPEP and PAK5

Data Source:
BioGRID (enzymatic study)

		DNPEP	PAK5
Description		aspartyl aminopeptidase	p21 (RAC1) activated kinase 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Blood Microparticle	Nucleoplasm Cytoplasm Mitochondrion Synapse
	Molecular Function	Aminopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Proteolysis Peptide Metabolic Process	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Activation of RAC1
Drugs		Glutamic acid	Fostamatinib
Diseases
GWAS		Height ( 31562340) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Urinary metabolite levels in chronic kidney disease ( 31959995)	Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)
Interacting Genes		8 interacting genes: ADAMTSL4 AGT DGCR6 LNX1 MDFI MPP1 PAK5 SAT1	34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT
Entrez ID		23549	57144
HPRD ID		09924	06423
Ensembl ID		ENSG00000123992	ENSG00000101349
Uniprot IDs		A0A024R443 B7Z7F0 E5RIA4 E7ETB3 Q9ULA0	B0AZM9 Q9P286
PDB IDs		4DYO	2F57
Enriched GO Terms of Interacting Partners?
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