PNPLA2 and CYTH2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PNPLA2	CYTH2
Description		patatin like phospholipase domain containing 2	cytohesin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Integral Component Of Membrane	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Growth Cone
	Molecular Function	Triglyceride Lipase Activity Retinyl-palmitate Esterase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Diacylglycerol Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Lipid Homeostasis	Endocytosis Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Intra-Golgi traffic
Drugs			Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) HDL cholesterol levels ( 32203549) Keratoconus ( 31855235)	Abstraction and mental flexibility ( 31596458)
Interacting Genes		10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2	31 interacting genes: ADORA2A ALDOA APC ARF1 ARF6 ARFGAP1 ARL4A ARL4D ARRB1 ARRB2 ATP6V0A1 ATP6V0A2 ATP6V0A4 CCDC120 CNKSR1 CUX1 CYTIP DOCK1 GGA3 GNAQ INAVA IPCEF1 ITGB2 MAPK6 PIK3CA PNPLA2 PRKCA PRKCB PRKCG TCIRG1 TRIM23
Entrez ID		57104	9266
HPRD ID		11443	03925
Ensembl ID		ENSG00000177666	ENSG00000105443
Uniprot IDs		Q96AD5	Q99418
PDB IDs			1PBV 1R8M 1R8Q 1R8S 1S9D 4JMI 4JMO 4JWL 4JXH 4L5M 4Z21
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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