PNPLA2 and FAF2

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		PNPLA2	FAF2
Description		patatin like phospholipase domain containing 2	Fas associated factor family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Integral Component Of Membrane	Extracellular Region Endoplasmic Reticulum Lipid Droplet VCP-NPL4-UFD1 AAA ATPase Complex Azurophil Granule Lumen
	Molecular Function	Triglyceride Lipase Activity Retinyl-palmitate Esterase Activity	Protein Binding Ubiquitin Protein Ligase Binding Lipase Binding Ubiquitin Binding Lipase Inhibitor Activity
	Biological Process	Diacylglycerol Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Lipid Homeostasis	Response To Unfolded Protein Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization Negative Regulation Of Catalytic Activity Neutrophil Degranulation
Pathways		Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Neutrophil degranulation
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) HDL cholesterol levels ( 32203549) Keratoconus ( 31855235)
Interacting Genes		10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2	11 interacting genes: ELAVL1 FAF1 FAS MAP3K1 PCAT1 PNPLA2 PSMD2 SMURF1 UBE2D1 UBE3A VCP
Entrez ID		57104	23197
HPRD ID		11443	16870
Ensembl ID		ENSG00000177666	ENSG00000113194
Uniprot IDs		Q96AD5	Q96CS3
PDB IDs			2DAM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?