PNPLA2 and ABHD5

Data Source:
BioGRID (fluorescent resonance energy transfer, protein complementation assay)

		PNPLA2	ABHD5
Description		patatin like phospholipase domain containing 2	abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Integral Component Of Membrane	Nucleoplasm Mitochondrion Lipid Droplet Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Triglyceride Lipase Activity Retinyl-palmitate Esterase Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Triglyceride Lipase Activity Protein Binding Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Diacylglycerol Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Lipid Homeostasis	Fatty Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Cell Differentiation Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis
Pathways		Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Triglyceride catabolism
Drugs
Diseases			Dorfman-Chanarin syndrome; Chanarin-Dorfman syndrome
GWAS		Body fat distribution (arm fat ratio) ( 30664634) HDL cholesterol levels ( 32203549) Keratoconus ( 31855235)	General risk tolerance (MTAG) ( 30643258) Inflammatory skin disease ( 25574825)
Interacting Genes		10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2	21 interacting genes: CERCAM COQ8A DGAT2L6 GAD2 GET1 GRIA4 MIEF1 PCNX2 PLIN1 PLIN2 PLIN3 PNPLA2 RBFA RNF24 RUSC1 SH3GLB1 SLC44A3 TMEM14B TMEM31 TPD52L2 ZCCHC12
Entrez ID		57104	51099
HPRD ID		11443	11986
Ensembl ID		ENSG00000177666	ENSG00000011198
Uniprot IDs		Q96AD5	A0A0S2Z5D6 Q8WTS1
PDB IDs
Enriched GO Terms of Interacting Partners?
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