HOOK2 and APEX2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HOOK2	APEX2
Description		hook microtubule tethering protein 2	apurinic/apyrimidinic endodeoxyribonuclease 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Microtubule HOPS Complex Intracellular Membrane-bounded Organelle FHF Complex	Fibrillar Center Nucleus Nucleoplasm Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding	DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Phosphodiesterase I Activity Protein Binding Zinc Ion Binding Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity
	Biological Process	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport	Base-excision Repair DNA Recombination Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		121 interacting genes: ABLIM1 AKTIP ANKRD11 ANKRD36BP1 AP1M1 APEX2 ATG5 BYSL C1orf109 CABP2 CBX8 CCDC187 CCDC198 CCDC33 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13 EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEANC TCHP TPM3 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844	17 interacting genes: APP CALCOCO2 CCDC85B DAPK1 EFEMP2 HOOK2 LRRK2 MAP3K1 MFHAS1 MKRN3 NEDD4L NINL PCNA PGR TRAF2 TRIM37 TSHZ3
Entrez ID		29911	27301
HPRD ID		09698	06442
Ensembl ID		ENSG00000095066	ENSG00000169188
Uniprot IDs		Q96ED9	B4DWI9 B7ZA71 E5KN95 Q9UBZ4
PDB IDs
Enriched GO Terms of Interacting Partners?
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