PSMB1 and TRAF1

Data Source:
BioGRID (two hybrid, two hybrid)

		PSMB1	TRAF1
Description		proteasome 20S subunit beta 1	TNF receptor associated factor 1
Image
GO Annotations	Cellular Component	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Plasma Membrane Signaling Receptor Complex
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding
	Biological Process	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Proteasomal Ubiquitin-independent Protein Catabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neutrophil Degranulation Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation	Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Protein-containing Complex Assembly Protein K63-linked Ubiquitination Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway
Drugs		Bortezomib (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Carfilzomib
Diseases
GWAS		Blood protein levels ( 30072576) Type 1 diabetes ( 21980299)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Pulse pressure ( 30578418) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314 24782177 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) White blood cell count ( 32888494)
Interacting Genes		105 interacting genes: AGR2 AHSP ARNT2 BEND7 BIRC7 BPIFA1 CAMK2G CCM2L CDC14B CDC42 CDKN1B CLPP COG6 CTAG1A CTAG1B CYTH4 DCP2 DDI1 EXOSC6 FAM136A FAM50B FANCG GADD45GIP1 GEMIN2 GEMIN4 GPBP1 GRIPAP1 GTPBP2 HMG20A HOXA1 IMPACT INSIG2 JAKMIP1 KATNBL1 KHDC4 KIFC3 KRT13 KRT15 KRT31 KRT34 KRT36 KRT40 KRTAP15-1 KRTAP19-1 KRTAP19-7 KRTAP7-1 LCE1C LCE1F LDB2 LENG1 LHX3 LIN7B LMO1 LZTFL1 MAPRE3 MKRN3 MLKL MRNIP MTUS2 NANOS3 NME4 OIP5 OTUD7B PIP4K2B PLEKHG4 PLK1 POMP PSEN1 PSMA1 PSMB3 PSMB4 PSMB5 PSMB7 PSMG3 PYCR3 RIPPLY3 RNF8 RPRD1B RWDD2A RYBP SCARA5 SERPINB2 SH3GL1 SMAD3 SMARCB1 STMN2 TFPT THAP6 TLE5 TOLLIP TRAF1 TRAF2 TRIM23 TRIM27 TRIM39 TTC33 UBASH3B VAX1 XPA ZBTB32 ZNF177 ZNF438 ZNF559-ZNF177 ZNF688 ZNF774	245 interacting genes: A1CF ABHD17A ACTN3 AKAP17A AQP1 ARID5A ARNT2 ARSJ BARD1 BCAS2 BCL6 BEX2 BEX3 BIRC2 BIRC3 C1orf109 C1orf216 C2CD6 C4orf45 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCDC185 CCDC187 CCDC198 CCHCR1 CD40 CDCA3 CDK18 CDKN1A CDKN2B CFLAR CHCHD3 COX5B CRACR2A CRY2 CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 DUSP13 DUSP21 DUSP4 EBF2 EDAR EHHADH ENKD1 EWSR1 FAM161A FAM161B FAM86C1P FBF1 FBXL18 FOSL2 GADD45GIP1 GATA1 GATA2 GATAD2B GCA GCM2 GEM GFI1B GIT2 GLIS3 GLRX3 GMCL2 GNG5 GOLGA2 GORASP2 GRAP2 HAUS1 HELT HEY2 HGS HIVEP3 HMG20B HNRNPM HOXA1 HOXB5 HOXC8 HOXD12 IKBKB JOSD1 KANK2 KIAA1217 KIF1A KLHL38 KPNA2 KRT3 KRT75 LATS1 LCOR LIN37 LMNTD2 LNX1 LNX2 LRRN1 LTBR MACIR MAP3K14 MAP6 MAPRE2 MATR3 METTL17 MORN3 MOS MSGN1 MYEF2 MYOZ1 NEBL NOL4L-DT NTAQ1 NUFIP2 NUP58 OLIG3 PATZ1 PBX3 PDE4D PHF21A PIN1 PITX1 PITX2 PKN1 PLAC8 PLEKHN1 POM121L4P POP5 PPP1R13B PPP1R32 PRDM7 PRKAB2 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RCOR3 RIIAD1 RIPK1 RIPK2 RIPOR3 RIPPLY1 RNF31 RTP5 SAMD11 SCNM1 SDCBP2 SH3GLB2 SHARPIN SHC3 SHFL SIK3 SLC25A48 SLC25A6 SNRNP25 SNW1 SOHLH1 SPATA46 SPG21 SPOP SRC SSC5D STK3 SUMO2 SYCE1 TANK TBC1D16 TBC1D8 TBX18 TCEA2 TCF7L2 TCL1A TEAD4 TFAP2D TFAP4 TFPT THAP7 TICAM1 TIFA TLE5 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSHZ2 TSSC4 USP2 USP7 UTP14C VEZF1 WAC ZBTB1 ZBTB16 ZC2HC1C ZFYVE21 ZFYVE26 ZIC1 ZNF124 ZNF20 ZNF23 ZNF250 ZNF417 ZNF440 ZNF490 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF627 ZNF648 ZNF662 ZNF669 ZNF688 ZNF697 ZNF844
Entrez ID		5689	7185
HPRD ID		03603	03418
Ensembl ID		ENSG00000008018	ENSG00000056558
Uniprot IDs		A0A140VK45 P20618	Q13077
PDB IDs		4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5L5B 5L5D 5L5E 5L5F 5L5H 5L5I 5L5J 5L5O 5L5P 5L5Q 5L5R 5L5S 5L5T 5L5U 5L5V 5L5W 5L5X 5L5Y 5L5Z 5L60 5L61 5L62 5L63 5L64 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M2B 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ	3M0D 5E1T 5H10
Enriched GO Terms of Interacting Partners?
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