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PSMA1 and CBS
Data Source:
BioGRID
(two hybrid)
PSMA1
CBS
Description
proteasome 20S subunit alpha 1
cystathionine beta-synthase
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Proteasome Core Complex
Polysome
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Exosome
Nucleus
Cytoplasm
Cytosol
Molecular Function
Lipopolysaccharide Binding
RNA Binding
Endopeptidase Activity
Protein Binding
Cystathionine Beta-synthase Activity
Protein Binding
Oxygen Binding
Enzyme Binding
Heme Binding
Pyridoxal Phosphate Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Nitrite Reductase (NO-forming) Activity
Carbon Monoxide Binding
Nitric Oxide Binding
Modified Amino Acid Binding
S-adenosyl-L-methionine Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Cysteine Biosynthetic Process From Serine
L-serine Metabolic Process
L-serine Catabolic Process
Cysteine Biosynthetic Process Via Cystathionine
Cysteine Biosynthetic Process
Transsulfuration
L-cysteine Catabolic Process
DNA Protection
Homocysteine Catabolic Process
Homocysteine Metabolic Process
Hydrogen Sulfide Biosynthetic Process
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Cysteine formation from homocysteine
Cysteine formation from homocysteine
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Pyridoxal phosphate
Ademetionine
Serine
Cysteine
Diseases
Homocystinuria
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
Bipolar disorder (
31043756
)
Diastolic blood pressure (
27841878
)
HDL cholesterol levels (
32203549
)
High chromosomal aberration frequency (total) (
31586183
)
Systolic blood pressure (
27841878
)
Triglyceride levels (
32203549
32154731
)
Vitamin D levels (
25208829
)
Blood and toenail selenium levels (
25343990
)
Blood metabolite levels (
24816252
)
Blood trace element (Se levels) (
23720494
)
Homocysteine levels (
23824729
20031578
)
Neutrophil count (
32888494
)
Obesity-related traits (
23251661
)
Plasma homocysteine levels (post-methionine load test) (
24651765
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Interacting Genes
169 interacting genes:
ABCD3
ABI2
ABI3
ACTN1
ACTN2
AGR2
APIP
APP
BANF2
BLZF1
C11orf49
C22orf39
CABP5
CALCOCO2
CBS
CCDC102B
CCDC136
CCDC153
CCDC85B
CCNH
CDA
CDKN2D
CDR2
CEP70
CEP72
CFAP206
CHMP1A
CINP
COG4
COG6
COIL
CRX
DCTD
DCTPP1
DDIT4L
DEF6
DLEU1
DYDC1
DYNLT1
EHMT2
EIF4A3
EMSY
ERBB2
FNDC11
GNPTAB
GOLGA2
GOLGA6A
GPHN
GSDMD
GUCD1
HEXIM2
HOMER3
HOMEZ
HOOK2
HOXC11
HSD17B14
HSF2BP
IFT20
IKZF1
IKZF3
INO80E
IPO13
KAZN
KCTD1
KCTD13
KCTD17
KCTD6
KCTD7
KCTD9
KHDRBS3
KRT13
KRT15
KRT19
KRT31
KRT34
KRT37
KRT38
KRT40
KRTAP1-1
KRTAP1-3
KRTAP4-1
KRTAP5-9
KRTAP6-3
LDB1
LDOC1
LMO2
LONRF1
LZTFL1
LZTS1
LZTS2
MAD1L1
MAPK1
MAPRE1
MAPRE3
MCM6
MID2
MIEF1
MKNK2
MKRN3
MLH1
MRFAP1L1
MSANTD4
MT-CO2
MTUS2
NAB2
NBPF19
NECAB2
NME7
NMI
NOP53
NOTCH2NLA
PCBD1
PCYT2
PICK1
PLK1
PM20D2
PNMA1
PNMA2
PNMA5
POLR1C
POMP
PPCDC
PRDM14
PRIMPOL
PRKN
PRPH
PSMA2
PSMA3
PSMA4
PSMA7
PSMB1
PSMB10
PSMB2
PSMB5
RAD54B
RBCK1
REL
RFC2
RGS19
ROPN1
SAT1
SFMBT1
SH3BP4
SH3GLB1
SLF2
SPDEF
SSX2IP
TCF12
TCF4
TDO2
TEKT4
TNFAIP1
TNR
TRAF1
TRAF5
TRIM10
TRIM23
TRIM27
TRIM42
TRIM54
TSC22D4
UBXN11
VCP
VIM
VMAC
WTAP
YPEL5
ZFAND1
ZMYND19
23 interacting genes:
CBX4
CERT1
DAXX
EHHADH
FXR2
HGS
HID1
HTT
NTAQ1
PIAS1
PIAS2
PIAS3
PIN1
PRKAG1
PRKAR1A
PSMA1
RANBP9
UBASH3A
UBE2I
UGP2
VTA1
ZDHHC17
ZMYM5
Entrez ID
5682
875
HPRD ID
04170
01994
Ensembl ID
ENSG00000129084
ENSG00000160200
Uniprot IDs
B4E0X6
P25786
B7Z2D6
P0DN79
P35520
Q9NTF0
PDB IDs
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
1JBQ
1M54
4COO
4L0D
4L27
4L28
4L3V
4PCU
4UUU
5MMS
Enriched GO Terms of Interacting Partners
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