MASP1 and RPS6KA6

Data Source:
BioGRID (two hybrid)

		MASP1	RPS6KA6
Description		MBL associated serine protease 1	ribosomal protein S6 kinase A6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Complement Activation, Lectin Pathway Proteolysis Receptor-mediated Endocytosis Complement Activation	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors	Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation
Drugs			Fostamatinib
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Impulsivity (attentional) ( 30718321) Type 2 diabetes ( 30130595)
Interacting Genes		16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1	28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746
Entrez ID		5648	27330
HPRD ID		02749	02250
Ensembl ID		ENSG00000127241	ENSG00000072133
Uniprot IDs		F8W876 P48740	Q9UK32
PDB IDs		3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD	6G76 6G77 6G78
Enriched GO Terms of Interacting Partners?
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