PRSS2 and MKKS

Data Source:
BioGRID (affinity chromatography technology)

		PRSS2	MKKS
Description		serine protease 2	McKusick-Kaufman syndrome
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Azurophil Granule Lumen	Nucleus Cytoplasm Centrosome Cytosol Motile Cilium Kinociliary Basal Body
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding ATP Binding Unfolded Protein Binding
	Biological Process	Proteolysis Digestion Antimicrobial Humoral Response Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Collagen Catabolic Process Neutrophil Degranulation Positive Regulation Of Cell Adhesion	Heart Looping Protein Folding Spermatid Development Determination Of Left/right Symmetry Heart Development Visual Perception Sensory Perception Of Smell Gonad Development Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Actin Filament Polymerization Melanosome Transport Developmental Process Negative Regulation Of GTPase Activity Social Behavior Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Vasodilation Fat Cell Differentiation Photoreceptor Cell Maintenance Negative Regulation Of Blood Pressure Intracellular Transport Brain Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chaperone-mediated Protein Complex Assembly Cartilage Development Regulation Of Stress Fiber Assembly Pigment Granule Aggregation In Cell Center Convergent Extension Involved In Gastrulation Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Non-motile Cilium Assembly
Pathways		Collagen degradation Alpha-defensins Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides	BBSome-mediated cargo-targeting to cilium
Drugs		Monoisopropylphosphorylserine O-Benzylsulfonyl-Serine Benzylamine Benzamidine Phosphorylisopropane Phenethylamine 3-Phenylpropylamine
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis	46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome Bardet-Biedl syndrome (BBS)
GWAS		Blood protein levels ( 29875488) Pancreatitis ( 23143602)
Interacting Genes		7 interacting genes: APP BPI CSN1S1 GLP1R MMP9 SERPINA1 SLPI	4 interacting genes: APP CDR2 PTN ZBED1
Entrez ID		5645	8195
HPRD ID		03335	05356
Ensembl ID		ENSG00000275896	ENSG00000125863
Uniprot IDs		A6XMV9 P07478 Q5NV56 Q6PK75	B7Z3W9 Q9NPJ1
PDB IDs
Enriched GO Terms of Interacting Partners?
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