PROP1 and PSMB4

Data Source:
BioGRID (two hybrid)

		PROP1	PSMB4
Description		PROP paired-like homeobox 1	proteasome 20S subunit beta 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Ciliary Basal Body Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Lipopolysaccharide Binding Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Pituitary Gland Development	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Amino Acid Metabolic Process Proteasomal Ubiquitin-independent Protein Catabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation
Pathways			Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs			(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Blood trace element (Cu levels) ( 23720494) Body mass index ( 26426971)
Interacting Genes		54 interacting genes: ABHD11 ARSA BATF2 C11orf1 C19orf54 C1orf94 C6orf15 C9orf24 COX6B2 CRYBA1 CYSRT1 DAZAP2 EFEMP2 FAM166A FAM168A HDHD3 HESX1 HNRNPF HOXA1 INTS11 KHDC1 KRTAP13-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-3 KRTAP8-1 MAGED1 METTL15 METTL27 NR1D2 OLIG3 OXER1 P4HA3 PITX2 PLEKHB2 POU6F2 PSMB11 PSMB4 RNF144B RNF4 SMUG1 SUMO1 TBX22 TEKT4 TEKT5 TENT5B TINAGL1 TLE5 TMEM42 TRIM42 UBE2I UFSP1 ZNF503	35 interacting genes: APP BCL6 C1orf109 CCDC57 CNOT2 CUL1 DTX2 FSD2 GABARAPL1 GCA HEMK1 HGS KANK2 KRTAP19-5 MYOZ3 OAZ1 P4HA3 PFDN5 PITX2 PKN1 PLK1 PRKCA PROP1 PRPF19 PSMB1 PSMB5 PSMD2 PSMG3 SMAD1 SOHLH1 SPG21 SYNPO2L TEKT5 TFAP2D TLE5
Entrez ID		5626	5692
HPRD ID		03325	03710
Ensembl ID		ENSG00000175325	ENSG00000159377
Uniprot IDs		A0A0G2JQ02 O75360	A0A140VK46 P28070
PDB IDs			4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ
Enriched GO Terms of Interacting Partners?
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