PRODH and GSC2

Data Source:
BioGRID (affinity chromatography technology)

		PRODH	GSC2
Description		proline dehydrogenase 1	goosecoid homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Intracellular Membrane-bounded Organelle	Chromatin Nucleus
	Molecular Function	Proline Dehydrogenase Activity FAD Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Proline Metabolic Process Proline Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Proline Catabolic Process To Glutamate Positive Regulation Of Cell Death 4-hydroxyproline Catabolic Process	Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis
Pathways		Proline catabolism
Drugs		Proline
Diseases		Hyperprolinemia (HP)
GWAS		Amino acid levels ( 26068415) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Metabolic traits ( 21886157) Metabolite levels ( 31628463) Neutrophil count ( 32888494) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free proline levels ( 30659259) Platelet count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 25569235) White blood cell count ( 32888494)	Metabolite levels ( 22916037)
Interacting Genes			60 interacting genes: ALPP ANXA5 ASPH BEST3 BNIP2 C19orf47 C1D CALM1 CALM2 CALM3 CALR CDKN2D CIAO2A COL8A1 CRCP CSNK2A1 DYRK1B EGLN3 EIF5A ETFDH FAM221B FKBP6 GALNT11 GCM2 GTF2H5 GTSF1L GUCA1A GUCY1A2 HMBOX1 ISX KDM6A KLHL38 KRT34 KRTAP5-9 LCE3E LTO1 MAD2L2 MAPK9 MARF1 MID2 MORF4L1 MRPL53 MRPS23 NME7 PACSIN2 PDE4C PRKAB2 PTER RNF4 SCAF1 SDCBP TIPIN TNPO2 TSR2 UBE2R2 VCX2 XRCC4 YPEL5 ZNF444 ZNF587
Entrez ID		5625	2928
HPRD ID		08433	03506
Ensembl ID		ENSG00000100033	ENSG00000063515
Uniprot IDs		O43272	O15499
PDB IDs
Enriched GO Terms of Interacting Partners?
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