GSC2 and PDE4C

Data Source:
BioGRID (two hybrid)

		GSC2	PDE4C
Description		goosecoid homeobox 2	phosphodiesterase 4C
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Extracellular Space Nucleus Cytosol Cilium Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways			DARPP-32 events G alpha (s) signalling events
Drugs			Caffeine Dyphylline Iloprost Amrinone Roflumilast Piclamilast Crisaborole Ibudilast Exisulind Trapidil
Diseases
GWAS		Metabolite levels ( 22916037)	Apolipoprotein B levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Urate levels ( 31578528)
Interacting Genes		60 interacting genes: ALPP ANXA5 ASPH BEST3 BNIP2 C19orf47 C1D CALM1 CALM2 CALM3 CALR CDKN2D CIAO2A COL8A1 CRCP CSNK2A1 DYRK1B EGLN3 EIF5A ETFDH FAM221B FKBP6 GALNT11 GCM2 GTF2H5 GTSF1L GUCA1A GUCY1A2 HMBOX1 ISX KDM6A KLHL38 KRT34 KRTAP5-9 LCE3E LTO1 MAD2L2 MAPK9 MARF1 MID2 MORF4L1 MRPL53 MRPS23 NME7 PACSIN2 PDE4C PRKAB2 PTER RNF4 SCAF1 SDCBP TIPIN TNPO2 TSR2 UBE2R2 VCX2 XRCC4 YPEL5 ZNF444 ZNF587	9 interacting genes: DDIT4L GSC2 KLRK1 MEOX1 MEOX2 OSGIN1 PAX6 SRI ZNF280A
Entrez ID		2928	5143
HPRD ID		03506	02529
Ensembl ID		ENSG00000063515	ENSG00000105650
Uniprot IDs		O15499	O43849 P78505 Q08493 Q32MM7 Q7KYS4
PDB IDs			1LXU 2QYM
Enriched GO Terms of Interacting Partners?
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