PROC and CFLAR

Data Source:
BioGRID (genetic interference)

		PROC	CFLAR
Description		protein C, inactivator of coagulation factors Va and VIIIa	CASP8 and FADD like apoptosis regulator
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Ripoptosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Protease Binding Death Receptor Binding Protein Binding Enzyme Activator Activity Protein-containing Complex Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Development Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Viral Process Cellular Response To Insulin Stimulus Response To Testosterone Wound Healing Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Apoptotic Signaling Pathway Execution Phase Of Apoptosis Negative Regulation Of Myoblast Fusion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	TRAIL signaling
Drugs		Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human
Diseases		Inherited thrombophilia
GWAS		Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)	Rheumatoid arthritis ( 30423114 24390342) Triptolide cytotoxicity ( 26121980)
Interacting Genes		15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	25 interacting genes: BCL2L1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 DAXX DEDD DEDD2 FADD IKBKB MAP2K4 MAP2K7 NFKB1 PSEN2 RAF1 RIPK1 RIPK2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 USP8
Entrez ID		5624	8837
HPRD ID		01466	04671
Ensembl ID		ENSG00000115718	ENSG00000003402
Uniprot IDs		P04070	A0A024R3Y3 A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61
PDB IDs		1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C	2N5R 3H11 3H13
Enriched GO Terms of Interacting Partners?
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