MAPK4 and CCND3

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MAPK4	CCND3
Description		mitogen-activated protein kinase 4	cyclin D3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle Intracellular Signal Transduction	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Signal Transduction T Cell Proliferation Regulation Of Cell Population Proliferation Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Insulin Receptor Signaling Pathway Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		MAPK6/MAPK4 signaling	Transcriptional regulation of white adipocyte differentiation MAPK6/MAPK4 signaling Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs		Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 28135244) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Large HDL particle concentration ( 29084231) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418) White blood cell count ( 32888494)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Cardiometabolic and hematological traits ( 27668658) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549 28334899) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematological parameters ( 19820697) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 29403010 32888494 28453575 20139978 27863252 28017375 19862010) Mean corpuscular hemoglobin concentration ( 32888494 28017375) Mean corpuscular volume ( 23263863 29403010 32888494 28453575 20139978 27863252 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 21507922) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494 20139978 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: CALML3 CCND3 CRK GAB1 GAB2 MAPKAPK5	56 interacting genes: AKAP8 APP AREG ATF5 ATP5F1C C14orf119 CASP2 CCDC13 CDK11B CDK14 CDK16 CDK18 CDK3 CDK4 CDK5 CDK6 CDKN1A CDKN1B CDKN2D CRABP2 DMRTB1 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS FHL3 GC HGS KIFC3 LSM3 MAF1 MAPK4 MAPK6 MCM10 MNS1 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL PSMC1 QKI RARA RB1 RBL2 RUNX1 SH3GLB2 SIL1 TEX11 TFIP11 TSG101 VDR
Entrez ID		5596	896
HPRD ID		01497	00452
Ensembl ID		ENSG00000141639	ENSG00000112576
Uniprot IDs		B4DEW2 K7ELV1 P31152	B3KP19 D6RI00 P30281 Q5T8J1
PDB IDs			3G33
Enriched GO Terms of Interacting Partners?
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