MAPK4 and GAB1

Data Source:
HPRD (in vitro)

		MAPK4	GAB1
Description		mitogen-activated protein kinase 4	GRB2 associated binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytosol Cell-cell Junction
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle Intracellular Signal Transduction	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Cytoskeleton Reorganization Response To Hepatocyte Growth Factor Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase B Signaling Endothelial Cell Chemotaxis To Vascular Endothelial Growth Factor
Pathways		MAPK6/MAPK4 signaling	PI3K Cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PIP3 activates AKT signaling GAB1 signalosome PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling MET activates PTPN11 MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants
Drugs		Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 28135244) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Large HDL particle concentration ( 29084231) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418) White blood cell count ( 32888494)	Asthma ( 21804548) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 31562340) Malaria ( 31844061) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		6 interacting genes: CALML3 CCND3 CRK GAB1 GAB2 MAPKAPK5	73 interacting genes: ARHGAP32 BCAR3 BLK BLNK BTK C1QBP CRK CRKL EGFR EPOR ERBB2 FCGR2B FES FRS2 GAB2 GRAP2 GRB2 GTF2A1L HCK HSH2D INPP5D INPPL1 INSR ITK JAK1 LAT2 LCK LYN MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R NCK1 NCK2 PDGFRB PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK6 PTPN11 PTPN18 RASA1 RET SH2D1B SH2D2A SH2D3A SHC1 SHC3 SLA SLA2 SOCS3 SOCS6 SOS1 SRC STAP1 SUPT6H SYK SYP TEC TNS1 TNS3 TNS4 TRIM15 VAV1 VAV2 VAV3 YES1
Entrez ID		5596	2549
HPRD ID		01497	05116
Ensembl ID		ENSG00000141639	ENSG00000109458
Uniprot IDs		B4DEW2 K7ELV1 P31152	Q13480 Q9HA84
PDB IDs			4QSY
Enriched GO Terms of Interacting Partners?
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