MAPK4 and GAB2

Data Source:
HPRD (in vitro)

		MAPK4	GAB2
Description		mitogen-activated protein kinase 4	GRB2 associated binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle Intracellular Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Osteoclast Differentiation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Mast Cell Degranulation Phosphatidylinositol-mediated Signaling
Pathways		MAPK6/MAPK4 signaling	PI3K Cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Constitutive Signaling by Aberrant PI3K in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Interleukin-15 signaling Interleukin receptor SHC signaling FLT3 Signaling FLT3 Signaling STAT5 Activation STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants
Drugs		Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 28135244) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Large HDL particle concentration ( 29084231) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418) White blood cell count ( 32888494)	Alzheimer's disease (late onset) ( 17553421) Alzheimer's disease (survival time) ( 25649651) Blond vs. brown/black hair color ( 30531825) Body mass index ( 28892062) Brown vs. black hair color ( 30531825) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Hair color ( 29662168) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29785010) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 30275531) Lipid traits (pleiotropy) (HIPO component 2) ( 30289880) Menarche (age at onset) ( 21102462 25231870) Platelet distribution width ( 32888494) Testicular germ cell tumor ( 28604728 28604732 26503584) Total cholesterol levels ( 30275531) Tourette syndrome ( 30818990) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		6 interacting genes: CALML3 CCND3 CRK GAB1 GAB2 MAPKAPK5	29 interacting genes: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 MYO15B NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SRC SYK TNFRSF11A ZAP70
Entrez ID		5596	9846
HPRD ID		01497	05866
Ensembl ID		ENSG00000141639	ENSG00000033327
Uniprot IDs		B4DEW2 K7ELV1 P31152	Q9UQC2
PDB IDs			2VWF 2W0Z 5EWZ 5EXA
Enriched GO Terms of Interacting Partners?
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