GABRQ and GNMT

Data Source:
BioGRID (two hybrid)

		GABRQ	GNMT
Description		gamma-aminobutyric acid type A receptor subunit theta	glycine N-methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Chloride Channel Complex Neuron Projection Receptor Complex Synapse Postsynaptic Membrane GABA-A Receptor Complex	Cytosol
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Neurotransmitter Transmembrane Transporter Activity Protein Binding Neurotransmitter Receptor Activity	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding
	Biological Process	Neurotransmitter Transport Signal Transduction Chemical Synaptic Transmission Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Chloride Transmembrane Transport	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation	Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam	Ademetionine Glycine S-adenosyl-L-homocysteine
Diseases			Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS			Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)
Interacting Genes		1 interacting genes: GNMT	30 interacting genes: ADAMTSL4 ARR3 ARRB1 CCDC153 COX7B CTNS FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337
Entrez ID		55879	27232
HPRD ID		02284	05970
Ensembl ID		ENSG00000268089	ENSG00000124713
Uniprot IDs		Q9UN88	A0A0S2Z5F2 Q14749 V9HW60
PDB IDs			1R74 2AZT
Enriched GO Terms of Interacting Partners?
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