GNMT and SRD5A2

Data Source:
BioGRID (two hybrid)

		GNMT	SRD5A2
Description		glycine N-methyltransferase	steroid 5 alpha-reductase 2
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GO Annotations	Cellular Component	Cytosol	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Protein Binding Sterol 5-alpha Reductase Activity Oxidoreductase Activity Testosterone Dehydrogenase [NAD(P)] Activity Cholestenone 5-alpha-reductase Activity
	Biological Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process	Steroid Biosynthetic Process Androgen Biosynthetic Process Cell-cell Signaling Androgen Metabolic Process Male Gonad Development Cell Differentiation Male Genitalia Development Testosterone Biosynthetic Process
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation	Androgen biosynthesis
Drugs		Ademetionine Glycine S-adenosyl-L-homocysteine	Spironolactone Azelaic acid Dutasteride Finasteride
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency	46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)	Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Idiopathic pulmonary fibrosis ( 29066090) Inflammatory biomarkers ( 24182552) Male-pattern baldness ( 29146897 27182965 28196072) Zinc levels ( 26025379)
Interacting Genes		30 interacting genes: ADAMTSL4 ARR3 ARRB1 CCDC153 COX7B CTNS FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337	2 interacting genes: CYSRT1 GNMT
Entrez ID		27232	6716
HPRD ID		05970	07390
Ensembl ID		ENSG00000124713	ENSG00000277893
Uniprot IDs		A0A0S2Z5F2 Q14749 V9HW60	P31213
PDB IDs		1R74 2AZT	7BW1
Enriched GO Terms of Interacting Partners?
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