GNMT and FRG1

Data Source:
BioGRID (two hybrid)

		GNMT	FRG1
Description		glycine N-methyltransferase	FSHD region gene 1
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GO Annotations	Cellular Component	Cytosol	Nucleolus Cajal Body Z Disc Striated Muscle Dense Body Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding	RNA Binding Protein Binding Actin Filament Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process	MRNA Splicing, Via Spliceosome RRNA Processing Muscle Organ Development
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation
Drugs		Ademetionine Glycine S-adenosyl-L-homocysteine
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)	Brain volume in infants (cerebrospinal fluid) ( 28763065) Periodontitis (CDC/AAP) ( 24024966) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)
Interacting Genes		30 interacting genes: ADAMTSL4 ARR3 ARRB1 CCDC153 COX7B CTNS FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337	5 interacting genes: EXOSC8 GNMT KRT40 LZTS2 RBPMS
Entrez ID		27232	2483
HPRD ID		05970	03176
Ensembl ID		ENSG00000124713	ENSG00000109536
Uniprot IDs		A0A0S2Z5F2 Q14749 V9HW60	Q14331
PDB IDs		1R74 2AZT	6ZYM 7A5P
Enriched GO Terms of Interacting Partners?
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