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PBK and H2AX
Data Source:
BioGRID
(enzymatic study)
PBK
H2AX
Description
PDZ binding kinase
H2A.X variant histone
Image
GO Annotations
Cellular Component
Nucleus
Chromosome, Telomeric Region
Nucleosome
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Centrosome
Nuclear Speck
Site Of Double-strand Break
Extracellular Exosome
Site Of DNA Damage
Molecular Function
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
MAPK Cascade
Activation Of MAPK Activity
Mitotic Cell Cycle
Negative Regulation Of Protein Phosphorylation
Protein Phosphorylation
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Stress-activated MAPK Cascade
Cellular Response To UV
Negative Regulation Of Inflammatory Response
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Nucleosome Assembly
Chromatin Silencing
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Viral Process
Cerebral Cortex Development
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Cellular Response To Gamma Radiation
Cellular Senescence
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
GWAS
Interacting Genes
19 interacting genes:
ARAF
CCNB1
CDK1
CEP126
DLG1
GPRASP1
GPS2
H2AX
LNX1
MCRS1
PTEN
RAF1
SMAD4
TERT
TP53
TRIM37
ZBTB26
ZFP64
ZNF526
46 interacting genes:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
EYA1
HUWE1
KAT5
MASP1
MDC1
MRE11
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PRKDC
PTPA
QARS1
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TRAF6
TSSK6
WRN
Entrez ID
55872
3014
HPRD ID
17822
03465
Ensembl ID
ENSG00000168078
ENSG00000188486
Uniprot IDs
Q96KB5
V9HWH0
P16104
PDB IDs
5J0A
1YDP
2AZM
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
6K1I
6K1J
6K1K
Enriched GO Terms of Interacting Partners
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