HDAC5 and BRMS1

Data Source:
HPRD (in vivo)

		HDAC5	BRMS1
Description		histone deacetylase 5	BRMS1 transcriptional repressor and anoikis regulator
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding Repressing Transcription Factor Binding	Protein Binding Histone Deacetylase Binding NF-kappaB Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Chromatin Silencing Protein Deacetylation Inflammatory Response Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Histone Deacetylation Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Response To Drug Regulation Of Protein Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Histone H3 Deacetylation Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Histone H3-K9 Acetylation	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Deacetylation Positive Regulation Of Anoikis
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription	HDACs deacetylate histones Potential therapeutics for SARS
Drugs		Belinostat Panobinostat
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Bipolar disorder ( 31043756) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) Mean platelet volume ( 32888494)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		61 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 LMO2 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16	49 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SUDS3 TAF1 THRSP UBE2D1
Entrez ID		10014	25855
HPRD ID		09246	05879
Ensembl ID		ENSG00000108840	ENSG00000174744
Uniprot IDs		Q9UQL6	G5E9I4 Q9HCU9
PDB IDs		5UWI	2XUS 4AUV
Enriched GO Terms of Interacting Partners?
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