CAND1 and CNOT3

Data Source:
HPRD (in vitro, two hybrid)

		CAND1	CNOT3
Description		cullin associated and neddylation dissociated 1	CCR4-NOT transcription complex subunit 3
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cullin-RING Ubiquitin Ligase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	P-body Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Protein Binding TBP-class Protein Binding	Protein Binding
	Biological Process	Cellular Iron Ion Homeostasis SCF Complex Assembly Protein Ubiquitination Cell Differentiation Negative Regulation Of Catalytic Activity Neutrophil Degranulation Post-translational Protein Modification Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly	Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Silencing By RNA Positive Regulation Of Cold-induced Thermogenesis Regulation Of Stem Cell Population Maintenance
Pathways		Neutrophil degranulation Neddylation Iron uptake and transport	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Expressive vocabulary in infants ( 25226531) HDL cholesterol levels ( 32203549) Hippocampal atrophy ( 19668339) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549)	PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)
Interacting Genes		18 interacting genes: CA9 CNOT3 CUL1 CUL2 CUL3 CUL4A CUL4B DCUN1D1 DCUN1D2 DCUN1D4 DCUN1D5 DUX4 LNPK MTNR1A RBX1 SKP1 SRPK2 UBE2M	8 interacting genes: CAND1 CAND2 CNOT1 CNOT2 CNOT4 CNOT8 CREBBP ID3
Entrez ID		55832	4849
HPRD ID		06983	05368
Ensembl ID		ENSG00000111530	ENSG00000088038
Uniprot IDs		Q86VP6	A0A024R4R3 O75175
PDB IDs		1U6G 4A0C	4C0D 4C0G 5FU6 5FU7
Enriched GO Terms of Interacting Partners?
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