CAND1 and DCUN1D2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		CAND1	DCUN1D2
Description		cullin associated and neddylation dissociated 1	defective in cullin neddylation 1 domain containing 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cullin-RING Ubiquitin Ligase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Protein Binding TBP-class Protein Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Cellular Iron Ion Homeostasis SCF Complex Assembly Protein Ubiquitination Cell Differentiation Negative Regulation Of Catalytic Activity Neutrophil Degranulation Post-translational Protein Modification Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly	Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways		Neutrophil degranulation Neddylation Iron uptake and transport	Neddylation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Expressive vocabulary in infants ( 25226531) HDL cholesterol levels ( 32203549) Hippocampal atrophy ( 19668339) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549)	Birth weight ( 31043758) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)
Interacting Genes		18 interacting genes: CA9 CNOT3 CUL1 CUL2 CUL3 CUL4A CUL4B DCUN1D1 DCUN1D2 DCUN1D4 DCUN1D5 DUX4 LNPK MTNR1A RBX1 SKP1 SRPK2 UBE2M	7 interacting genes: APP CAND1 CUL2 CUL3 MAP3K1 UBE2F UBE2M
Entrez ID		55832	55208
HPRD ID		06983	12614
Ensembl ID		ENSG00000111530	ENSG00000150401
Uniprot IDs		Q86VP6	Q6PH85
PDB IDs		1U6G 4A0C	4GAO
Enriched GO Terms of Interacting Partners?
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