CCAR1 and U2AF2

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CCAR1	U2AF2
Description		cell division cycle and apoptosis regulator 1	U2 small nuclear RNA auxiliary factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Nucleoplasm Perinuclear Region Of Cytoplasm	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Coactivator Activity	RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Apoptotic Process Cell Cycle Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Cannabis dependence symptom count ( 27028160)	HDL cholesterol levels ( 32203549) Menopause (age at onset) ( 26414677)
Interacting Genes		14 interacting genes: CASP10 CHERP DNAAF6 GOLGA2 HMGB1 HNRNPK MDM2 MIR106B MIRLET7G MTUS2 RBM10 RNF113A SFN U2AF2	75 interacting genes: APBB1 ATXN1 BEND7 CCAR1 CDC42 CHERP CHIC2 CPSF7 DACH1 DDX39B DDX6 DPPA2 DVL2 EPB41 FUBP1 GEMIN2 GLIS2 HLA-DMA HMBOX1 IL7R INO80B KHDC4 KHDRBS3 LURAP1 MAP1B MRPL15 NKAPD1 OTUB2 PHF5A PIN1 POLR2A PRPF3 PRPF40A PUF60 QKI RBFOX2 RBM11 RBM39 RBM4 RBMY1F RBMY1J SAP30BP SCAF11 SF1 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SRSF3 STAC3 SUGP1 SUMO2 TCERG1 TCF23 THAP1 TLE5 TOP1 U2AF1 U2AF1L5 WT1 ZNF107 ZNF526 ZNF57 ZNF71 ZNF835 ZRSR2 ZRSR2P1
Entrez ID		55749	11338
HPRD ID		10811	01872
Ensembl ID		ENSG00000060339	ENSG00000063244
Uniprot IDs		Q8IX12	P26368
PDB IDs			1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H 6TR0 6XLV 6XLW 6XLX
Enriched GO Terms of Interacting Partners?
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