PARVA and FERMT2

Data Source:
BioGRID (pull down)

		PARVA	FERMT2
Description		parvin alpha	FERM domain containing kindlin 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion Cell Cortex Cell Surface Cell Junction Cell-substrate Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Lamellipodium Membrane I Band
	Molecular Function	Actin Binding Protein Kinase Inhibitor Activity Protein Binding Cadherin Binding	Actin Binding Integrin Binding Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding SMAD Binding Actin Filament Binding
	Biological Process	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Negative Regulation Of Protein Kinase Activity Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Assembly Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Protein Stabilization Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Integrin Activation Positive Regulation Of Integrin Activation Cell Junction Assembly Adherens Junction Maintenance Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Myosin Light Chain Kinase Activity Negative Regulation Of Vascular Permeability Positive Regulation Of GTPase Activity Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Focal Adhesion Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Limb Development Negative Regulation Of Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Protein Localization To Cell Junction Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778)	Alzheimer's disease (late onset) ( 24162737) Diastolic blood pressure ( 27841878) Glaucoma (primary angle closure) ( 27064256) Intraocular pressure ( 29617998 29785010 31959993 30054594) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 30046033 32439900) Prostate cancer ( 23535732) Pulse pressure ( 27841878) Systolic blood pressure ( 28135244 27841878)
Interacting Genes		14 interacting genes: ACTA1 APP FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 PXN UBE3A UBQLN1	8 interacting genes: APP CMTM5 FBLIM1 ILK ITGB1 LIMS1 PARVA TRIM15
Entrez ID		55742	10979
HPRD ID		16283	06374
Ensembl ID		ENSG00000197702	ENSG00000073712
Uniprot IDs		Q9NVD7	A0A024R687 Q96AC1
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB	2LGX 2LKO 2MSU 4F7H 6U4N 6XTJ
Enriched GO Terms of Interacting Partners?
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