PARVA and NFE2L1

Data Source:
BioGRID (two hybrid)

		PARVA	NFE2L1
Description		parvin alpha	nuclear factor, erythroid 2 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane
	Molecular Function	Actin Binding Protein Kinase Inhibitor Activity Protein Binding Cadherin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Lipid Binding
	Biological Process	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Negative Regulation Of Protein Kinase Activity Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Assembly Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Protein Stabilization Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis	Regulation Of Transcription By RNA Polymerase II Heme Biosynthetic Process Cholesterol Metabolic Process Anatomical Structure Morphogenesis Cellular Response To Oxidative Stress
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs			Dodecyldimethylamine N-oxide
Diseases
GWAS		Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778)	Generalized epilepsy ( 22949513) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		14 interacting genes: ACTA1 APP FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 PXN UBE3A UBQLN1	16 interacting genes: ATF4 BACH2 CAPN1 CD6 CREBZF GSK3B HCFC1 JUN JUNB JUND MAFF MAFG MAFK NFE2L3 PARVA TULP3
Entrez ID		55742	4779
HPRD ID		16283	01223
Ensembl ID		ENSG00000197702	ENSG00000082641
Uniprot IDs		Q9NVD7	J9JIE5 Q14494 Q8NF22
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB
Enriched GO Terms of Interacting Partners?
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