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FERMT2 and ILK
Data Source:
BioGRID
(biochemical, pull down, pull down, affinity chromatography technology)
FERMT2
ILK
Description
FERM domain containing kindlin 2
integrin linked kinase
Image
GO Annotations
Cellular Component
Stress Fiber
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Focal Adhesion
Cell Cortex
Cell Surface
Cell Junction
Cell-substrate Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Lamellipodium Membrane
I Band
Stress Fiber
Nucleoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Sarcomere
Lamellipodium
Molecular Function
Actin Binding
Integrin Binding
Protein Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Protein Kinase Binding
Type I Transforming Growth Factor Beta Receptor Binding
SMAD Binding
Actin Filament Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Cell Adhesion
Cell-matrix Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Cell Shape
Positive Regulation Of Epithelial To Mesenchymal Transition
Wnt Signaling Pathway
Regulation Of Cell Morphogenesis
Positive Regulation Of Cell Migration
Integrin Activation
Positive Regulation Of Integrin Activation
Cell Junction Assembly
Adherens Junction Maintenance
Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Myosin Light Chain Kinase Activity
Negative Regulation Of Vascular Permeability
Positive Regulation Of GTPase Activity
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Focal Adhesion Assembly
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Limb Development
Negative Regulation Of Cell Death
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Localization To Membrane
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Protein Localization To Nucleus
Protein Localization To Cell Junction
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Cell Morphogenesis
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Positive Regulation Of Signal Transduction
Tumor Necrosis Factor-mediated Signaling Pathway
Cell Junction Assembly
Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Phosphorylation
Positive Regulation Of Transcription, DNA-templated
Platelet Aggregation
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of NIK/NF-kappaB Signaling
Pathways
Cell-extracellular matrix interactions
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Alzheimer's disease (late onset) (
24162737
)
Diastolic blood pressure (
27841878
)
Glaucoma (primary angle closure) (
27064256
)
Intraocular pressure (
29617998
29785010
31959993
30054594
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
PR interval (
30046033
32439900
)
Prostate cancer (
23535732
)
Pulse pressure (
27841878
)
Systolic blood pressure (
28135244
27841878
)
Malaria (
31844061
)
Interacting Genes
8 interacting genes:
APP
CMTM5
FBLIM1
ILK
ITGB1
LIMS1
PARVA
TRIM15
42 interacting genes:
AKT1
CASP8
CASP9
CAV1
CKB
FERMT1
FERMT2
FERMT3
GSK3B
ILKAP
ITGB1
ITGB2
ITGB3
LIMS1
LIMS2
MATK
MBP
MIPEP
NCK2
NOTCH1
PARVA
PARVB
PARVG
PDPK1
PPP1R12A
PTPN11
PXN
RICTOR
RNF19A
RPL13
SERPINA4
SHC1
SNRNP35
SUMO2
TMSB4X
TRIM27
TWF2
ZBTB48
ZNF133
ZNF205
ZNF579
ZNF746
Entrez ID
10979
3611
HPRD ID
06374
03842
Ensembl ID
ENSG00000073712
ENSG00000166333
Uniprot IDs
A0A024R687
Q96AC1
Q13418
V9HWF0
PDB IDs
2LGX
2LKO
2MSU
4F7H
6U4N
6XTJ
2KBX
3F6Q
3IXE
3KMU
3KMW
3REP
4HI8
4HI9
6MIB
Enriched GO Terms of Interacting Partners
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