PARVA and FERMT1

Data Source:
BioGRID (pull down)

		PARVA	FERMT1
Description		parvin alpha	FERM domain containing kindlin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Junction Cell-substrate Junction Ruffle Membrane Cell Periphery
	Molecular Function	Actin Binding Protein Kinase Inhibitor Activity Protein Binding Cadherin Binding	Integrin Binding Actin Filament Binding
	Biological Process	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Negative Regulation Of Protein Kinase Activity Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Assembly Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Protein Stabilization Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis	Positive Regulation Of Cell-matrix Adhesion Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Integrin Activation Positive Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Protein Import Into Nucleus Keratinocyte Proliferation Keratinocyte Migration Negative Regulation Of Timing Of Anagen Positive Regulation Of Transforming Growth Factor Beta Production Basement Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Establishment Of Epithelial Cell Polarity Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Stem Cell Proliferation
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases			Kindler syndrome
GWAS		Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778)	Abdominal aortic aneurysm ( 27899403) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung function (low FEV1 vs high FEV1) ( 26423011) Retinal detachment or retinal break ( 31816047) Smooth-surface caries ( 24556642) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		14 interacting genes: ACTA1 APP FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 PXN UBE3A UBQLN1	4 interacting genes: ILK ITGB1 PARVA SRPK1
Entrez ID		55742	55612
HPRD ID		16283	06388
Ensembl ID		ENSG00000197702	ENSG00000101311
Uniprot IDs		Q9NVD7	Q49AC8 Q54A15 Q9BQL6
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB
Enriched GO Terms of Interacting Partners?
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