ARFGAP1 and GGCX

Data Source:
HPRD (in vitro)

		ARFGAP1	GGCX
Description		ADP ribosylation factor GTPase activating protein 1	gamma-glutamyl carboxylase
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Synapse	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Gamma-glutamyl Carboxylase Activity Vitamin Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction IRE1-mediated Unfolded Protein Response Positive Regulation Of GTPase Activity	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation
Pathways		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis	Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9
Drugs			Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
Diseases			Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS			Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)
Interacting Genes		34 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23	7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2
Entrez ID		55738	2677
HPRD ID		06443	00665
Ensembl ID		ENSG00000101199	ENSG00000115486
Uniprot IDs		Q53F62 Q8N6T3	P38435
PDB IDs		3DWD 3O47
Enriched GO Terms of Interacting Partners?
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