GGCX and BGLAP

Data Source:
HPRD (in vitro)

		GGCX	BGLAP
Description		gamma-glutamyl carboxylase	bone gamma-carboxyglutamate protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Golgi Lumen Dendrite Vesicle Perikaryon
	Molecular Function	Gamma-glutamyl Carboxylase Activity Vitamin Binding	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Bone Hydroxyapatite Binding
	Biological Process	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation	Skeletal System Development Osteoblast Differentiation Osteoblast Development Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cell Adhesion Cell Aging Response To Mechanical Stimulus Response To Gravity Response To Zinc Ion Response To Activity Bone Mineralization Regulation Of Bone Mineralization Response To Vitamin K Response To Vitamin D Response To Testosterone Response To Hydroxyisoflavone Odontogenesis Response To Drug Response To Estrogen Regulation Of Bone Resorption Response To Ethanol Regulation Of Osteoclast Differentiation Response To Glucocorticoid Bone Development Cellular Response To Vitamin D Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Insulin Stimulus
Pathways		Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9	Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins RUNX2 regulates osteoblast differentiation
Drugs		Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human	Menadione Phylloquinone gamma-carboxy-L-glutamic acid Gallium nitrate
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)	Estimated glomerular filtration rate ( 30604766) Mean corpuscular hemoglobin concentration ( 20139978) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) White matter hyperintensity burden ( 25663218)
Interacting Genes		7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2	6 interacting genes: ASPH CTSB CTSD CTSH CTSS GGCX
Entrez ID		2677	632
HPRD ID		00665	00205
Ensembl ID		ENSG00000115486	ENSG00000242252
Uniprot IDs		P38435	P02818
PDB IDs
Enriched GO Terms of Interacting Partners?
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