TNP1 and PPARD

Data Source:
BioGRID (two hybrid)

		TNP1	PPARD
Description		transition protein 1	peroxisome proliferator activated receptor delta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Male Germ Cell Nucleus Nucleus	Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Lipid Binding NF-kappaB Binding Linoleic Acid Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Single Strand Break Repair Nucleosome Disassembly Chromatin Remodeling Chromatin Silencing Multicellular Organism Development Spermatid Development Spermatid Nucleus Differentiation Spermatid Nucleus Elongation Positive Regulation Of Protein Processing Sexual Reproduction Flagellated Sperm Motility Fertilization, Exchange Of Chromosomal Proteins Spermatogenesis, Exchange Of Chromosomal Proteins Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Glucose Metabolic Process Proteoglycan Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Vitamin A Metabolic Process Apoptotic Process Heart Development Embryo Implantation Cholesterol Metabolic Process Cell Population Proliferation Axon Ensheathment Phospholipid Biosynthetic Process Fatty Acid Catabolic Process Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Cholesterol Storage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Transport Regulation Of Lipid Metabolic Process Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Cell-substrate Adhesion Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Response To Lipid Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Wound Healing Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Regeneration Keratinocyte Proliferation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Epidermis Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Decidualization Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Keratinocyte Migration Adipose Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Apoptotic Signaling Pathway Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Glucose Transmembrane Transport Positive Regulation Of Myoblast Proliferation
Pathways			Carnitine metabolism Regulation of pyruvate dehydrogenase (PDH) complex Nuclear Receptor transcription pathway Signaling by Retinoic Acid
Drugs			alpha-Linolenic acid Icosapent Troglitazone Valproic acid Treprostinil Rosiglitazone Sulindac Bezafibrate Phthalic Acid Heptyl glucoside Oleic Acid cis-Vaccenic acid Elafibranor KD3010 Cardarine (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid Indeglitazar {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid Clinofibrate Glycerin Fenofibric acid Fish oil
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate ( 29403010) Height ( 25282103 31562340) Hypothyroidism ( 27182965) Mitral valve prolapse ( 26301497) Permanent tooth development ( 21931568) Pulse pressure ( 27841878) Thyroid stimulating hormone levels ( 32769997)	Cataracts in type 2 diabetes ( 23137000) Childhood body mass index ( 33045005) Gout ( 22179738) Heel bone mineral density ( 30598549) Height ( 21998595 28552196) Lymphocyte counts ( 27863252) Platelet count ( 32888494) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment ( 20195266)
Interacting Genes		10 interacting genes: CSNK2A1 DVL3 PPARA PPARD PPARG PRKACA PRKACB PRKACG PRKCA SDCBP2	43 interacting genes: BCL6 CEP350 DUT EP300 GADD45B GADD45G GLUL HDAC1 HDAC2 HDAC3 HDAC4 HDAC7 HSP90AA1 ITGB5 KDM1A KRTAP10-3 KRTAP10-7 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR0B2 NR1H2 NR1H3 NRIP1 PEBP1 PPARGC1A PRDX6 PRMT3 PROX1 PSMC5 RANBP9 RXRA RXRB RXRG SHMT2 SMAD9 SPEN SRC STAT3 TNP1 ZNF837
Entrez ID		7141	5467
HPRD ID		01830	02679
Ensembl ID		ENSG00000118245	ENSG00000112033
Uniprot IDs		P09430 Q4ZG82	A0A024RCW6 F1D8S7 Q03181
PDB IDs			1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM 5U3Q 5U3R 5U3S 5U3T 5U3U 5U3V 5U3W 5U3X 5U3Y 5U3Z 5U40 5U41 5U42 5U43 5U44 5U45 5U46 5XMX 5Y7X 5ZXI 6A6P
Enriched GO Terms of Interacting Partners?
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