PKIA and EGFR

Data Source:
HPRD (in vitro)

		PKIA	EGFR
Description		cAMP-dependent protein kinase inhibitor alpha	epidermal growth factor receptor
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Golgi Membrane Extracellular Space Nucleus Cytoplasm Endosome Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Basal Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cell Junction Endocytic Vesicle Clathrin-coated Vesicle Membrane Early Endosome Membrane Nuclear Membrane Protein-containing Complex Receptor Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding Protein Kinase A Catalytic Subunit Binding	Virus Receptor Activity Chromatin Binding Double-stranded DNA Binding MAP Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Epidermal Growth Factor-activated Receptor Activity Integrin Binding Protein Binding Calmodulin Binding ATP Binding Enzyme Binding Kinase Binding Protein Kinase Binding Protein Phosphatase Binding Nitric-oxide Synthase Regulator Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding Epidermal Growth Factor Binding Actin Filament Binding ATPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of CAMP-dependent Protein Kinase Activity	MAPK Cascade Activation Of MAPKK Activity Ossification Positive Regulation Of Protein Phosphorylation Hair Follicle Development Regulation Of Transcription By RNA Polymerase II Translation Response To Osmotic Stress Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Multicellular Organism Development Midgut Development Learning Or Memory Circadian Rhythm Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nitric Oxide Mediated Signal Transduction Magnesium Ion Homeostasis Regulation Of Phosphatidylinositol 3-kinase Signaling Diterpenoid Metabolic Process Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Peptidyl-serine Phosphorylation Response To Cobalamin Response To Hydroxyisoflavone Positive Regulation Of Kinase Activity Cellular Response To Reactive Oxygen Species Cellular Response To Drug Peptidyl-tyrosine Autophosphorylation ERBB2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Wound Healing Negative Regulation Of Protein Catabolic Process Positive Regulation Of Phosphorylation Ovulation Cycle Hydrogen Peroxide Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Tongue Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Viral Entry Into Host Cell Protein Autophosphorylation Astrocyte Activation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Projection Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Nitric-oxide Synthase Activity Protein Insertion Into Membrane Response To Calcium Ion Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Synaptic Transmission, Glutamatergic Membrane Organization Response To UV-A Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Cell-cell Adhesion Positive Regulation Of Protein Kinase C Activity Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Prolactin Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Cardiocyte Differentiation Regulation Of Cell Motility
Pathways			Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants
Drugs		3,5-Diiodotyrosine Hydroxyfasudil (2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE (2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine (2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE H-89 5-(2-methylpiperazine-1-sulfonyl)isoquinoline N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE 3-pyridin-4-yl-1H-indazole 5-benzyl-1,3-thiazol-2-amine 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium Fasudil Myristic acid A-674563 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE Y-27632	Cetuximab Lidocaine Gefitinib Erlotinib Lapatinib Panitumumab Alvocidib IGN311 Matuzumab Vandetanib Rindopepimut Canertinib Pelitinib Varlitinib AV-412 S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE PD-168393 Afatinib Osimertinib Necitumumab Foreskin keratinocyte (neonatal) Depatuxizumab mafodotin Icotinib Neratinib Dacomitinib Fostamatinib Zalutumumab Brigatinib Olmutinib Zanubrutinib Abivertinib
Diseases			Choriocarcinoma Gastric cancer Bladder cancer Oral cancer Glioma Laryngeal cancer Cervical cancer Esophageal cancer
GWAS		Femoral neck bone mineral density ( 22504420) Intraocular pressure ( 29617998 31959993) Multiple sclerosis ( 21833088) Optic disc size ( 31809533) Systemic lupus erythematosus ( 28714469) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)	Dental caries (decayed and filled deciduous teeth) ( 31533690) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 28346443 21531791 29743610) Impulsivity ( 30718321) Initial alcohol sensitivity ( 30276832) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Non-glioblastoma glioma ( 28346443) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Refractive astigmatism ( 30306274) Subjective response to lithium treatment ( 26503763)
Interacting Genes		12 interacting genes: AGFG1 CASP6 DYNLL1 DYNLL2 EGFR JUNB MRNIP PRC1 PRKACA PRKACB PRKX XPO1	409 interacting genes: ABL2 ACTA1 ADRM1 AGTR1 AHNAK AHSA1 AIP AKAP12 ALCAM ALDOA AMH ANKS1A ANKS1B ANXA1 AOPEP AP2B1 APBA3 APBB1 APBB3 APP APPL1 AR AREG ARF4 ARHGEF12 ARHGEF7 ARRB2 ATIC ATP1A1 ATP1B1 ATP5F1C AXL B4GALT1 BAIAP2 BCAR3 BLK BLNK BMX BTC CALM1 CALM2 CALM3 CAMK2A CAMK2G CAMLG CASP1 CAV1 CAV2 CAV3 CBL CBLB CBLC CCDC88A CD44 CD59 CD82 CDC25A CDC34 CDH1 CDH5 CDK1 CEACAM1 CEBPB CEND1 CFL1 CLNK CLTA CLTCL1 CMTM8 CNOT9 CNTN2 COL9A3 CRK CSRP1 CTNNB1 CTNND1 CTTN CYLC2 DCBLD2 DCN DCTN2 DEGS1 DNAJC4 DOK2 DOK4 DOK5 DOK6 DUSP19 DUSP3 DYNC1H1 EGF ELF3 EPB41 EPHA2 EPPK1 EPS15 EPS8 ERBB2 ERBB3 ERBB4 EREG ERRFI1 ESR1 EZR FAH FANCC FAS FBXO25 FER FES FGR FKBP4 FKBP8 FN1 FRAT2 FRK GAB1 GABARAPL2 GAPDH GGA1 GGA3 GJB1 GNAI2 GNAS GOT1 GPM6B GPNMB GRAP2 GRB10 GRB14 GRB2 GRB7 GRIN2B GRK2 H3-4 HBEGF HCK HDAC6 HDAC7 HEMGN HEXIM1 HGS HOXC10 HPN HSH2D HSP90AA1 HSP90AB1 HSP90B1 HSPA1A HSPA4 HSPA8 HTT ICAM1 IKBKG IL13RA2 IL5RA ILKAP INPPL1 IQGAP1 IRS1 IRS4 ITGA5 ITGB1 ITGB2 ITK ITSN2 JAK2 JUP KCTD9P2 KEAP1 KRT17 KRT18 KRT7 KRT8 LAT LCK LCP2 LINC01139 LRP1 LRRK1 LYN MAP2K1 MAP3K12 MAP3K14 MAP3K3 MAP4K1 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 MAPT MAST1 MATR3 MDH1 MEGF6 MET MGARP MIF MOB4 MT-CO2 MTDH MUC1 MUC4 NANS NCAM1 NCK1 NCK2 NDN NEDD4 NF2 NIBAN2 NR3C1 NRG1 NTRK2 NUMB NUMBL OAZ1 OLFM1 PAK1 PCNA PDCD6IP PDGFRA PDGFRB PDK3 PDP1 PFKP PIK3C2A PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PIM1 PIN4 PITPNA PKIA PLCG1 PLCG2 PLD1 PLD2 PLEC PLSCR1 PML PPARG PPM1A PPM1B PPP2CB PPP3CB PPP5C PRCC PRDX1 PRKACA PRKAR1A PRKAR1B PRKCA PRKCB PRKCD PRKCE PRKCZ PRKD1 PSMA7 PSMD4 PTGDS PTK2 PTK2B PTK6 PTPN1 PTPN11 PTPN12 PTPN18 PTPN2 PTPN20 PTPN22 PTPN6 PTPN7 PTPRB PTPRH PTPRJ PTPRR PTPRS PTPRT PTPRU RAB31 RAB3A RAF1 RAP1GDS1 RAPGEF1 RASA1 RGS16 RGS2 RGS4 RIN1 RIN2 RIPK1 RNF115 RNF126 RNF144A RRAD RUSC2 S100A4 S100A7 S100A9 SCAMP1 SCAMP3 SEC13 SELENOP SFN SGSM2 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH3BGRL3 SH3GL3 SHB SHC1 SHC2 SHC3 SHC4 SHD SHE SLA SLA2 SLC3A2 SLC9A3R1 SMURF2 SNCA SNRPD2 SNX1 SNX2 SNX4 SNX6 SNX9 SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOCS6 SOCS7 SORBS2 SOS1 SOS2 SPARCL1 SPCS2 SRC STAM2 STAP1 STAP2 STAT1 STAT2 STAT3 STAT5A STAT5B STIP1 STX17 STYX SUPT6H SYK TAB1 TEC TGFA TGFB1 TJP1 TLN1 TLR2 TMCO3 TNC TNFRSF1A TNK2 TNS1 TNS2 TNS3 TNS4 TPI1 TPM1 TRAF2 TRMO TRPV1 TSTD2 TUBA1A TUBA4A TXK TXN UBB UBE2V2 UCHL1 UROD VAPA VAV1 VAV2 VAV3 WASF3 WASL XRCC6 YES1 YWHAB YWHAQ YWHAZ ZAP70 ZNF510 ZPR1
Entrez ID		5569	1956
HPRD ID		05828	00579
Ensembl ID		ENSG00000171033	ENSG00000146648
Uniprot IDs		A0A024R7Y9 P61925	B7Z2I3 E7BSV0 E9PFD7 F2YGG7 P00533 Q504U8
PDB IDs		1CMK 1JLU 1Q8T 1VEB 1XH4 1XH5 1XH6 1XH7 1XH8 1XH9 1XHA 1YDR 2C1A 2C1B 2F7E 2GNI 2JDS 2JDT 2JDV 2L1L 2UVX 2UVY 2UVZ 2UW0 2UW3 2UW4 2UW5 2UW6 2UW7 2UW8 2VNW 2VNY 2VO0 2VO3 2VO6 2VO7 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 3WYG 3X2U 3X2V 3X2W 4AXA 4IAC 4IAD 4IAF 4IAI 4IAK 4IAY 4IAZ 4IB0 4IB1 4IB3 4IE9 4IJ9 4O21 4O22 4UJ1 4UJ2 4UJ9 4UJA 4UJB 4WB5 4WB6 4WB7 4WB8 4Z83 4Z84 5BX6 5BX7 5DH9 5LCP 5LCQ 5LCR 5LCT 5LCU 5M0B 5M0C 5M0L 5M0U 5M6V 5M6Y 5M71 5M75 5N23 5XOJ 6E21 6E99 6E9L 6FRX 6QJ7 6X2U 6X2V 6X2W	1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2EB2 2EB3 2EXP 2EXQ 2GS2 2GS6 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F 2J6M 2JIT 2JIU 2JIV 2KS1 2M0B 2M20 2N5S 2RF9 2RFD 2RFE 2RGP 3B2U 3B2V 3BEL 3BUO 3C09 3G5V 3G5Y 3GOP 3GT8 3IKA 3LZB 3NJP 3OB2 3OP0 3P0Y 3PFV 3POZ 3QWQ 3UG1 3UG2 3VJN 3VJO 3VRP 3VRR 3W2O 3W2P 3W2Q 3W2R 3W2S 3W32 3W33 4G5J 4G5P 4HJO 4I1Z 4I20 4I21 4I22 4I23 4I24 4JQ7 4JQ8 4JR3 4JRV 4KRL 4KRM 4KRO 4KRP 4LI5 4LL0 4LQM 4LRM 4R3P 4R3R 4R5S 4RIW 4RIX 4RIY 4RJ4 4RJ5 4RJ6 4RJ7 4RJ8 4TKS 4UIP 4UV7 4WD5 4WKQ 4WRG 4ZAU 4ZJV 4ZSE 5C8K 5C8M 5C8N 5CAL 5CAN 5CAO 5CAP 5CAQ 5CAS 5CAU 5CAV 5CNN 5CNO 5CZH 5CZI 5D41 5EDP 5EDQ 5EDR 5EM5 5EM6 5EM7 5EM8 5FED 5FEE 5FEQ 5GMP 5GNK 5GTY 5GTZ 5HCX 5HCY 5HCZ 5HG5 5HG7 5HG8 5HG9 5HIB 5HIC 5J9Y 5J9Z 5JEB 5LV6 5SX4 5SX5 5U8L 5UG8 5UG9 5UGA 5UGB 5UGC 5UWD 5WB7 5WB8 5X26 5X27 5X28 5X2A 5X2C 5X2F 5X2K 5XDK 5XDL 5XGM 5XGN 5XWD 5Y25 5Y9T 5YU9 5ZTO 5ZWJ 6ARU 6B3S 6D8E 6DUK 6JRJ 6JRK 6JRX 6JWL 6JX0 6JX4 6JXT 6JZ0 6LUB 6LUD 6P1D 6P1L 6P8Q 6S89 6S8A 6S9B 6S9C 6S9D 6TFU 6TFV 6TFW 6TFY 6TFZ 6TG0 6TG1 6V5N 6V5P 6V66 6V6K 6V6O 6VH4 6VHN 6VHP
Enriched GO Terms of Interacting Partners?
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