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PRKACA and CREB1
Data Source:
BioGRID
(enzymatic study)
PRKACA
CREB1
Description
protein kinase cAMP-activated catalytic subunit alpha
cAMP responsive element binding protein 1
Image
GO Annotations
Cellular Component
Acrosomal Vesicle
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Centrosome
Cytosol
Axoneme
CAMP-dependent Protein Kinase Complex
Membrane
Nuclear Speck
Neuromuscular Junction
Calcium Channel Complex
Sperm Flagellum
Dendritic Spine
Plasma Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Ciliary Base
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Mitochondrial Matrix
Axon
ATF4-CREB1 Transcription Factor Complex
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Domain Specific Binding
Manganese Ion Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Regulatory Subunit Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Hsp70 Protein Binding
Histone Acetyltransferase Binding
CAMP Response Element Binding
Identical Protein Binding
Arrestin Family Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Mesoderm Formation
Neural Tube Closure
Regulation Of Heart Rate
Stimulatory C-type Lectin Receptor Signaling Pathway
Renal Water Homeostasis
MRNA Processing
Protein Phosphorylation
Blood Coagulation
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Kinase A Signaling
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cytokine-mediated Signaling Pathway
Activation Of Protein Kinase A Activity
High-density Lipoprotein Particle Assembly
Cellular Response To Heat
Calcium-mediated Signaling Using Intracellular Calcium Source
Regulation Of Protein Binding
Regulation Of Osteoblast Differentiation
Protein Autophosphorylation
Positive Regulation Of Protein Export From Nucleus
Sperm Capacitation
Modulation Of Chemical Synaptic Transmission
Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Cardiac Muscle Contraction
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Processing
Positive Regulation Of Cell Cycle Arrest
Cellular Response To Glucose Stimulus
Cellular Response To Parathyroid Hormone Stimulus
Cellular Response To Glucagon Stimulus
Cellular Response To Epinephrine Stimulus
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Ciliary Basal Body-plasma Membrane Docking
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Regulation Of Cardiac Conduction
Regulation Of Bicellular Tight Junction Assembly
Response To Hypoxia
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Axonogenesis
Aging
Lactation
Memory
Circadian Rhythm
Regulation Of Cell Size
Visual Learning
Response To Organic Substance
Negative Regulation Of Transcription By Competitive Promoter Binding
Response To Activity
Viral Process
Pituitary Gland Development
Positive Regulation Of Transforming Growth Factor Beta3 Production
Secretory Granule Organization
Response To Glucagon
Chemotaxis To Arachidonic Acid
Response To Nicotine
Cellular Response To Hepatocyte Growth Factor Stimulus
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Multicellular Organism Growth
Response To Drug
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Secretion
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Fibroblast Proliferation
Protein Stabilization
Positive Regulation Of Cardiac Muscle Tissue Development
Regulation Of Glial Cell Proliferation
Lung Saccule Development
Type I Pneumocyte Differentiation
Cellular Response To Zinc Ion
Cellular Response To Retinoic Acid
Cellular Response To Fatty Acid
Positive Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Neuron Death
Response To L-glutamate
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Leukemia Inhibitory Factor
Pathways
PKA-mediated phosphorylation of CREB
PKA-mediated phosphorylation of key metabolic factors
Triglyceride catabolism
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of Adenylate Cyclase
Interleukin-3, Interleukin-5 and GM-CSF signaling
Ion homeostasis
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
RET signaling
AURKA Activation by TPX2
HDL assembly
ROBO receptors bind AKAP5
Loss of phosphorylation of MECP2 at T308
Regulation of MECP2 expression and activity
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
ADORA2B mediated anti-inflammatory cytokines production
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Factors involved in megakaryocyte development and platelet production
PKA-mediated phosphorylation of CREB
CaMK IV-mediated phosphorylation of CREB
AKT phosphorylates targets in the nucleus
CREB phosphorylation
Transcriptional activation of mitochondrial biogenesis
Transcriptional activation of mitochondrial biogenesis
NOTCH2 intracellular domain regulates transcription
NCAM signaling for neurite out-growth
Circadian Clock
Circadian Clock
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Constitutive Signaling by AKT1 E17K in Cancer
Gastrin-CREB signalling pathway via PKC and MAPK
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
MECP2 regulates transcription factors
NGF-stimulated transcription
NGF-stimulated transcription
HCMV Early Events
Transcriptional regulation of granulopoiesis
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
ADORA2B mediated anti-inflammatory cytokines production
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Drugs
Pentanal
Balanol Analog 2
3-[(3-sec-butyl-4-hydroxybenzoyl)amino]azepan-4-yl 4-(2-hydroxy-5-methoxybenzoyl)benzoate
Phosphonothreonine
Balanol Analog 1
3,5-Diiodotyrosine
Balanol
Dexfosfoserine
S,S-(2-Hydroxyethyl)Thiocysteine
Hydroxyfasudil
(2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine
(2S)-1-{[5-(1H-Indazol-5-yl)-3-pyridinyl]oxy}-3-(7aH-indol-3-yl)-2-propanamine
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
(2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE
3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione
(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
(2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
(2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
H-89
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
3-pyridin-4-yl-1H-indazole
5-benzyl-1,3-thiazol-2-amine
1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
Fasudil
Myristic acid
A-674563
3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
Y-27632
Ellagic acid
Fostamatinib
Adenosine phosphate
Naloxone
Diseases
GWAS
Body mass index (
28892062
25673413
)
Diastolic blood pressure (
27841878
)
Food antigen IgG levels (
24962563
)
Mean corpuscular hemoglobin (
32888494
)
Refractive error (
32231278
)
Systolic blood pressure (
27841878
)
Interacting Genes
205 interacting genes:
AANAT
ABCA1
ACLY
ADCY5
ADD1
ADD2
AKAP14
AKAP8L
AKIP1
ANXA7
APC
APOBEC3G
ARFGEF3
ASIC1
ASIC3
ATF1
ATP2B1
AURKA
AVPI1
BAD
BCL2
BRAF
CACNA1C
CACNB2
CACNG2
CAD
CALD1
CAMKK2
CCDC88A
CCND1
CDK16
CDKN1A
CETN1
CFTR
CIITA
CLDN3
CLTC
CREB1
CREM
CRK
CSK
CUL5
CYP3A4
DMTN
DNAJC5
DOCK1
DRD1
DSP
EEF2K
EGFR
ERBB3
ESR1
ETV1
FBXW11
FOS
FXYD1
GABRB3
GABRR1
GAD1
GAD2
GFAP
GJA5
GJB1
GLI1
GMFB
GNA13
GNMT
GP1BB
GRIA1
GRIA4
GRK2
GSK3A
GSK3B
GUSB
GYS1
HAND1
HAND2
HDAC1
HDAC8
HIF1A
HMGCR
HMGN1
HMGN2
HNF4A
HNRNPD
HSP90AA1
HSPA4
HSPD1
IFNAR1
IQGAP1
IRF2
ITCH
ITGA2B
ITGA4
ITPKA
ITPKB
ITPR1
ITPR2
KCNH2
KCNJ12
KCNQ1
KDELR1
KLF1
KLHL3
LCK
LCP1
LIPE
LRP1
MAP2
MAP3K3
MAPT
MBP
MC4R
MEF2D
MEP1B
MGMT
MIP
NDRG1
NFKB1
NIN
NOLC1
NOS1
NOXA1
NR3C1
NSFL1C
NUP85
PDC
PDE3A
PDE3B
PDE4B
PDE4D
PDPK1
PFKFB1
PFKFB2
PHKA1
PHOX2A
PKIA
PKIB
PLIN1
PLN
POU2F1
PPP1R10
PPP1R17
PPP1R1B
PPP1R8
PPP1R9B
PRKAR1A
PRKAR1B
PRKAR2B
PSEN1
PSMD11
PTBP1
PTPN12
PTPN13
PTPN7
PTPRR
RAF1
RANBP9
RAP1A
RAP1B
RAP1GAP
RASGRF1
RASGRP3
RELA
RGS10
RGS13
RGS14
RHOA
RRAD
RSBN1
RYR1
RYR2
SI
SIK1
SIK3
SLC2A2
SLC4A4
SLC9A3R2
SNAP25
SNAPIN
SNPH
SPTBN1
SRC
STK11
STMN1
STMN2
STUB1
SYN1
SYN2
TH
THOP1
TNP1
TNP2
TPH1
TRIM55
TRIM63
TRIP10
UBE3A
UHRF1
USP20
VASP
VIM
VTN
WT1
YWHAZ
80 interacting genes:
ABL1
AGR2
AKT1
ATF1
ATF6
ATF7IP
ATM
ATR
CAMK2A
CCDC6
CEBPB
CHD3
CHD8
CREBBP
CREM
CRTC1
CRTC2
DNMT3L
DYRK1A
EDF1
ERG28
FHL5
GLI2
GSK3A
GSK3B
GTF2A1
GTF2F2
HIPK3
HIVEP1
HNF1B
HPS6
KAT5
KCNIP3
KIAA2026
MAPK14
MAPKAPK2
MTF2
NR3C1
PDX1
PIAS1
PIAS2
POGZ
POU2F1
PPP1CA
PRKACA
PRKG1
RAB1A
RBBP4
RECQL5
RFX3
RGS13
RNF111
RNF4
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KA5
SGK1
SMARCA4
SMARCA5
SMCO1
SOX9
SRA1
SREBF2
SRF
SUZ12
THRA
TOX4
TRIM22
TSSK4
UBE2I
VIM
YY1
ZHX1
ZMYM2
ZNF35
ZNF436
ZNF451
ZNF92
Entrez ID
5566
1385
HPRD ID
03382
00442
Ensembl ID
ENSG00000072062
ENSG00000118260
Uniprot IDs
A0A024R7J0
A8K8B9
P17612
B7Z5C6
P16220
Q53X93
Q5U0J5
PDB IDs
2GU8
3AGL
3AGM
3AMA
3AMB
3L9L
3L9M
3L9N
3MVJ
3NX8
3OOG
3OVV
3OWP
3OXT
3P0M
3POO
3VQH
4AE6
4AE9
4UJ1
4UJ2
4UJ9
4UJA
4UJB
4WB5
4WB6
4WB7
4WB8
5BX6
5BX7
5IZF
5IZJ
5J5X
5N23
5UZK
6BYR
6BYS
6C0U
6FRX
6NO7
6QJ7
2LXT
5ZK1
5ZKO
Enriched GO Terms of Interacting Partners
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