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CREB1 and ABL1
Data Source:
BioGRID
(pull down)
HPRD
(in vivo)
CREB1
ABL1
Description
cAMP responsive element binding protein 1
ABL proto-oncogene 1, non-receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Mitochondrial Matrix
Axon
ATF4-CREB1 Transcription Factor Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Actin Cytoskeleton
Nuclear Body
Dendrite
Cell Leading Edge
Nuclear Membrane
Protein-containing Complex
Neuronal Cell Body
Perinuclear Region Of Cytoplasm
Postsynapse
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Hsp70 Protein Binding
Histone Acetyltransferase Binding
CAMP Response Element Binding
Identical Protein Binding
Arrestin Family Protein Binding
Sequence-specific Double-stranded DNA Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Phosphotyrosine Residue Binding
DNA Binding
Transcription Coactivator Activity
Actin Monomer Binding
Nicotinate-nucleotide Adenylyltransferase Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Kinase Activity
SH3 Domain Binding
Syntaxin Binding
Manganese Ion Binding
Neuropilin Binding
SH2 Domain Binding
Ephrin Receptor Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Proline-rich Region Binding
Supercoiled DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Response To Hypoxia
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Axonogenesis
Aging
Lactation
Memory
Circadian Rhythm
Regulation Of Cell Size
Visual Learning
Response To Organic Substance
Negative Regulation Of Transcription By Competitive Promoter Binding
Response To Activity
Viral Process
Pituitary Gland Development
Positive Regulation Of Transforming Growth Factor Beta3 Production
Secretory Granule Organization
Response To Glucagon
Chemotaxis To Arachidonic Acid
Response To Nicotine
Cellular Response To Hepatocyte Growth Factor Stimulus
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Multicellular Organism Growth
Response To Drug
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Secretion
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Fibroblast Proliferation
Protein Stabilization
Positive Regulation Of Cardiac Muscle Tissue Development
Regulation Of Glial Cell Proliferation
Lung Saccule Development
Type I Pneumocyte Differentiation
Cellular Response To Zinc Ion
Cellular Response To Retinoic Acid
Cellular Response To Fatty Acid
Positive Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Neuron Death
Response To L-glutamate
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Leukemia Inhibitory Factor
Mitotic Cell Cycle
Neural Tube Closure
B-1 B Cell Homeostasis
Positive Regulation Of Protein Phosphorylation
B Cell Proliferation Involved In Immune Response
Transitional One Stage B Cell Differentiation
Mismatch Repair
Regulation Of Transcription, DNA-templated
Cellular Protein Modification Process
Protein Phosphorylation
Endocytosis
Autophagy
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
Response To Oxidative Stress
Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Peptidyl-tyrosine Phosphorylation
Cerebellum Morphogenesis
Negative Regulation Of Cell-cell Adhesion
Microspike Assembly
Actin Cytoskeleton Organization
Regulation Of Endocytosis
Regulation Of Cell Adhesion
Negative Regulation Of BMP Signaling Pathway
Regulation Of Axon Extension
Regulation Of Microtubule Polymerization
Regulation Of Cdc42 Protein Signal Transduction
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Osteoblast Proliferation
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Oxidative Stress
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
Signal Transduction In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Endothelial Cell Migration
Establishment Of Protein Localization
Regulation Of T Cell Differentiation
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Alpha-beta T Cell Differentiation
Protein Autophosphorylation
Spleen Development
Thymus Development
Collateral Sprouting
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Neuromuscular Process Controlling Balance
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Oxidoreductase Activity
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Stress Fiber Assembly
Mitochondrial Depolarization
Positive Regulation Of Focal Adhesion Assembly
Bergmann Glial Cell Differentiation
Neuroepithelial Cell Differentiation
Cellular Response To Hydrogen Peroxide
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
DNA Conformation Change
Cellular Response To Lipopolysaccharide
Negative Regulation Of Protein Serine/threonine Kinase Activity
Circulatory System Development
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Actin Filament Branching
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Phospholipase C Activity
Positive Regulation Of Neuron Death
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of Extracellular Matrix Organization
Cellular Response To Dopamine
Positive Regulation Of Microtubule Binding
Positive Regulation Of Actin Filament Binding
Regulation Of Modification Of Synaptic Structure
Positive Regulation Of Blood Vessel Branching
Activation Of Protein Kinase C Activity
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Cell Motility
Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Cytoskeleton Reorganization
Negative Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Cellular Senescence
Regulation Of Response To DNA Damage Stimulus
Pathways
PKA-mediated phosphorylation of CREB
CaMK IV-mediated phosphorylation of CREB
AKT phosphorylates targets in the nucleus
CREB phosphorylation
Transcriptional activation of mitochondrial biogenesis
Transcriptional activation of mitochondrial biogenesis
NOTCH2 intracellular domain regulates transcription
NCAM signaling for neurite out-growth
Circadian Clock
Circadian Clock
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Constitutive Signaling by AKT1 E17K in Cancer
Gastrin-CREB signalling pathway via PKC and MAPK
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
MECP2 regulates transcription factors
NGF-stimulated transcription
NGF-stimulated transcription
HCMV Early Events
Transcriptional regulation of granulopoiesis
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
ADORA2B mediated anti-inflammatory cytokines production
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Regulation of actin dynamics for phagocytic cup formation
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
Myogenesis
Myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Cyclin D associated events in G1
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
Drugs
Adenosine phosphate
Naloxone
ATP
Imatinib
Dasatinib
N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
Nilotinib
XL228
Bosutinib
2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
Myristic acid
PD-166326
5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
Regorafenib
Ponatinib
Fostamatinib
Brigatinib
Radotinib
Diseases
Chronic myeloid leukemia (CML)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Body mass index (
28892062
25673413
)
Diastolic blood pressure (
27841878
)
Food antigen IgG levels (
24962563
)
Mean corpuscular hemoglobin (
32888494
)
Refractive error (
32231278
)
Systolic blood pressure (
27841878
)
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Platelet count (
32888494
)
Red cell distribution width (
32888494
)
Response to amphetamines (
22952603
)
White blood cell count (
32888494
)
Interacting Genes
80 interacting genes:
ABL1
AGR2
AKT1
ATF1
ATF6
ATF7IP
ATM
ATR
CAMK2A
CCDC6
CEBPB
CHD3
CHD8
CREBBP
CREM
CRTC1
CRTC2
DNMT3L
DYRK1A
EDF1
ERG28
FHL5
GLI2
GSK3A
GSK3B
GTF2A1
GTF2F2
HIPK3
HIVEP1
HNF1B
HPS6
KAT5
KCNIP3
KIAA2026
MAPK14
MAPKAPK2
MTF2
NR3C1
PDX1
PIAS1
PIAS2
POGZ
POU2F1
PPP1CA
PRKACA
PRKG1
RAB1A
RBBP4
RECQL5
RFX3
RGS13
RNF111
RNF4
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KA5
SGK1
SMARCA4
SMARCA5
SMCO1
SOX9
SRA1
SREBF2
SRF
SUZ12
THRA
TOX4
TRIM22
TSSK4
UBE2I
VIM
YY1
ZHX1
ZMYM2
ZNF35
ZNF436
ZNF451
ZNF92
161 interacting genes:
ABI1
ABI2
ABL2
ACTA1
ADAM15
ANAPC15
ANKRA2
APBB1
APP
AR
ARHGAP17
ATM
ATR
BCAR1
BCR
BIN1
BRCA1
BTK
C3
CABLES1
CABLES2
CASP9
CAT
CAV1
CBL
CCND2
CD19
CDK1
CDK5
CDKN1A
CDKN1B
CDON
CREB1
CRK
CRKL
CTNND2
DAPK1
DDB1
DDB2
DENND2B
DOK1
DOK2
DOK3
DVL2
EMD
ENAH
EP300
EPHA3
EPHB2
ERBB2
ERBB3
ERBB4
EVL
FBXO7
GJA8
GPX1
GRB10
GRB2
GRIN2D
GTF2F1
HCK
HIPK2
HUWE1
INPPL1
JAK1
JAK2
JUN
KIT
KRT31
LATS2
LRRK1
MAP4K1
MAP4K5
MAPT
MAVS
MBP
MDM2
MICAL1
MUC1
NCK1
NCOA3
NCSTN
NEDD4
NEDD4L
NEDD9
NFKBIA
NTRK1
PAG1
PAK2
PDE4D
PDGFRB
PIK3R1
PLCG1
PLEKHA4
PLSCR1
POLR2A
PRDX1
PRKD1
PRKDC
PSTPIP1
PTPN12
PTPN18
PTPN6
PXN
RAD51
RAD51B
RAD52
RAD9A
RAN
RAPGEF1
RASA1
RB1
RFX1
RIN1
ROBO1
ROS1
RYBP
SFN
SH3BP1
SH3BP2
SHB
SHD
SHE
SLC9A2
SOCS3
SORBS1
SORBS2
SORBS3
SOS2
SPRR2A
SPTA1
SPTAN1
SRC
SRCIN1
SRPK2
STUB1
TERT
TMPO
TOPBP1
TP53
TP73
TRAF6
TUB
UBC
VAV1
WASF1
WASF2
WASL
WRNIP1
XPO1
XRCC6
YAP1
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZAP70
ZDHHC16
Entrez ID
1385
25
HPRD ID
00442
01809
Ensembl ID
ENSG00000118260
ENSG00000097007
Uniprot IDs
B7Z5C6
P16220
Q53X93
Q5U0J5
A0A024R8E2
P00519
Q59FK4
PDB IDs
2LXT
5ZK1
5ZKO
1AB2
1ABL
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
4J9B
4J9C
4J9D
4J9E
4J9F
4J9G
4J9H
4J9I
4JJB
4JJC
4JJD
4TWP
4WA9
4XEY
4YC8
4ZOG
5DC0
5DC4
5DC9
5HU9
5MO4
5NP2
5OAZ
6AMV
6AMW
6BL8
6NPE
6NPU
6NPV
6XR6
6XR7
6XRG
Enriched GO Terms of Interacting Partners
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