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CREB1 and YY1
Data Source:
BioGRID
(two hybrid)
CREB1
YY1
Description
cAMP responsive element binding protein 1
YY1 transcription factor
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Mitochondrial Matrix
Axon
ATF4-CREB1 Transcription Factor Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromatin Silencing Complex
Cytoplasm
Nuclear Matrix
Ino80 Complex
PcG Protein Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Hsp70 Protein Binding
Histone Acetyltransferase Binding
CAMP Response Element Binding
Identical Protein Binding
Arrestin Family Protein Binding
Sequence-specific Double-stranded DNA Binding
Four-way Junction DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
RNA Binding
Protein Binding
SMAD Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Response To Hypoxia
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Axonogenesis
Aging
Lactation
Memory
Circadian Rhythm
Regulation Of Cell Size
Visual Learning
Response To Organic Substance
Negative Regulation Of Transcription By Competitive Promoter Binding
Response To Activity
Viral Process
Pituitary Gland Development
Positive Regulation Of Transforming Growth Factor Beta3 Production
Secretory Granule Organization
Response To Glucagon
Chemotaxis To Arachidonic Acid
Response To Nicotine
Cellular Response To Hepatocyte Growth Factor Stimulus
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Multicellular Organism Growth
Response To Drug
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Secretion
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Fibroblast Proliferation
Protein Stabilization
Positive Regulation Of Cardiac Muscle Tissue Development
Regulation Of Glial Cell Proliferation
Lung Saccule Development
Type I Pneumocyte Differentiation
Cellular Response To Zinc Ion
Cellular Response To Retinoic Acid
Cellular Response To Fatty Acid
Positive Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Neuron Death
Response To L-glutamate
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair Via Homologous Recombination
Regulation Of Transcription By RNA Polymerase II
RNA Localization
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Anterior/posterior Pattern Specification
Response To UV-C
Negative Regulation Of Gene Expression
Protein Deubiquitination
B Cell Differentiation
Negative Regulation Of Interferon-beta Production
Cellular Response To UV
Response To Prostaglandin F
Positive Regulation Of Transcription By RNA Polymerase II
Cell Development
Camera-type Eye Morphogenesis
Chromosome Organization
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Interleukin-1
Immunoglobulin Heavy Chain V-D-J Recombination
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways
PKA-mediated phosphorylation of CREB
CaMK IV-mediated phosphorylation of CREB
AKT phosphorylates targets in the nucleus
CREB phosphorylation
Transcriptional activation of mitochondrial biogenesis
Transcriptional activation of mitochondrial biogenesis
NOTCH2 intracellular domain regulates transcription
NCAM signaling for neurite out-growth
Circadian Clock
Circadian Clock
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Constitutive Signaling by AKT1 E17K in Cancer
Gastrin-CREB signalling pathway via PKC and MAPK
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
MECP2 regulates transcription factors
NGF-stimulated transcription
NGF-stimulated transcription
HCMV Early Events
Transcriptional regulation of granulopoiesis
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
ADORA2B mediated anti-inflammatory cytokines production
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
UCH proteinases
DNA Damage Recognition in GG-NER
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Estrogen-dependent gene expression
Drugs
Adenosine phosphate
Naloxone
Diseases
GWAS
Body mass index (
28892062
25673413
)
Diastolic blood pressure (
27841878
)
Food antigen IgG levels (
24962563
)
Mean corpuscular hemoglobin (
32888494
)
Refractive error (
32231278
)
Systolic blood pressure (
27841878
)
Estimated glomerular filtration rate (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Pulse pressure (
30224653
)
Interacting Genes
80 interacting genes:
ABL1
AGR2
AKT1
ATF1
ATF6
ATF7IP
ATM
ATR
CAMK2A
CCDC6
CEBPB
CHD3
CHD8
CREBBP
CREM
CRTC1
CRTC2
DNMT3L
DYRK1A
EDF1
ERG28
FHL5
GLI2
GSK3A
GSK3B
GTF2A1
GTF2F2
HIPK3
HIVEP1
HNF1B
HPS6
KAT5
KCNIP3
KIAA2026
MAPK14
MAPKAPK2
MTF2
NR3C1
PDX1
PIAS1
PIAS2
POGZ
POU2F1
PPP1CA
PRKACA
PRKG1
RAB1A
RBBP4
RECQL5
RFX3
RGS13
RNF111
RNF4
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KA5
SGK1
SMARCA4
SMARCA5
SMCO1
SOX9
SRA1
SREBF2
SRF
SUZ12
THRA
TOX4
TRIM22
TSSK4
UBE2I
VIM
YY1
ZHX1
ZMYM2
ZNF35
ZNF436
ZNF451
ZNF92
90 interacting genes:
ALOXE3
APP
ATF2
ATF6
ATF7
AURKA
BAP1
BCCIP
BRCA1
CDKN2A
CEP76
CREB1
CRKL
CYSRT1
DNMT3L
E2F2
E2F3
EED
EP300
ESM1
FHL2
FKBP1A
FKBP3
GMCL1
GRN
GTF2I
HCFC1
HDAC2
HDAC3
HOXA11
IL10
INO80
KAT2B
KRTAP1-3
KRTAP1-5
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP12-3
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP4-2
KRTAP4-5
KRTAP5-6
KRTAP9-3
KRTAP9-8
LHX3
LHX4
MDFI
MED20
MTA2
MYC
NEDD4L
NFKB1
NOTCH1
NPM1
NR1H2
PLEKHF2
PPIA
PSMD9
RAF1
RUVBL1
RUVBL2
RYBP
SAP30
SF3A2
SKP2
SLC39A7
SMAD1
SMAD2
SMAD3
SMURF2
SP1
SPRY1
SREBF1
TESK1
TFCP2
TP53
TRIM42
TWIST1
UHRF2
VWC2
XAGE1A
XAGE1B
YAF2
ZNF232
ZNF85
ZRANB2
Entrez ID
1385
7528
HPRD ID
00442
02482
Ensembl ID
ENSG00000118260
ENSG00000100811
Uniprot IDs
B7Z5C6
P16220
Q53X93
Q5U0J5
P25490
PDB IDs
2LXT
5ZK1
5ZKO
1UBD
1ZNM
4C5I
Enriched GO Terms of Interacting Partners
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