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CREB1 and RPS6KA1
Data Source:
HPRD
(in vitro)
CREB1
RPS6KA1
Description
cAMP responsive element binding protein 1
ribosomal protein S6 kinase A1
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Mitochondrial Matrix
Axon
ATF4-CREB1 Transcription Factor Complex
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Hsp70 Protein Binding
Histone Acetyltransferase Binding
CAMP Response Element Binding
Identical Protein Binding
Arrestin Family Protein Binding
Sequence-specific Double-stranded DNA Binding
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Response To Hypoxia
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Axonogenesis
Aging
Lactation
Memory
Circadian Rhythm
Regulation Of Cell Size
Visual Learning
Response To Organic Substance
Negative Regulation Of Transcription By Competitive Promoter Binding
Response To Activity
Viral Process
Pituitary Gland Development
Positive Regulation Of Transforming Growth Factor Beta3 Production
Secretory Granule Organization
Response To Glucagon
Chemotaxis To Arachidonic Acid
Response To Nicotine
Cellular Response To Hepatocyte Growth Factor Stimulus
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Multicellular Organism Growth
Response To Drug
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Secretion
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Fibroblast Proliferation
Protein Stabilization
Positive Regulation Of Cardiac Muscle Tissue Development
Regulation Of Glial Cell Proliferation
Lung Saccule Development
Type I Pneumocyte Differentiation
Cellular Response To Zinc Ion
Cellular Response To Retinoic Acid
Cellular Response To Fatty Acid
Positive Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Neuron Death
Response To L-glutamate
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Leukemia Inhibitory Factor
Apoptotic Process
Cell Cycle
Signal Transduction
Peptidyl-serine Phosphorylation
Positive Regulation Of Cell Growth
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Translation In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Proliferation
Positive Regulation Of Hepatic Stellate Cell Activation
Pathways
PKA-mediated phosphorylation of CREB
CaMK IV-mediated phosphorylation of CREB
AKT phosphorylates targets in the nucleus
CREB phosphorylation
Transcriptional activation of mitochondrial biogenesis
Transcriptional activation of mitochondrial biogenesis
NOTCH2 intracellular domain regulates transcription
NCAM signaling for neurite out-growth
Circadian Clock
Circadian Clock
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Constitutive Signaling by AKT1 E17K in Cancer
Gastrin-CREB signalling pathway via PKC and MAPK
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
MECP2 regulates transcription factors
NGF-stimulated transcription
NGF-stimulated transcription
HCMV Early Events
Transcriptional regulation of granulopoiesis
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
ADORA2B mediated anti-inflammatory cytokines production
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Adenosine phosphate
Naloxone
Purvalanol A
Fostamatinib
Diseases
GWAS
Body mass index (
28892062
25673413
)
Diastolic blood pressure (
27841878
)
Food antigen IgG levels (
24962563
)
Mean corpuscular hemoglobin (
32888494
)
Refractive error (
32231278
)
Systolic blood pressure (
27841878
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Fasting plasma glucose (
31932636
)
Glucose homeostasis traits (
25524916
)
Lymphocyte counts (
32888494
)
Mean corpuscular volume (
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
30108155
)
White blood cell count (
32888494
)
Interacting Genes
80 interacting genes:
ABL1
AGR2
AKT1
ATF1
ATF6
ATF7IP
ATM
ATR
CAMK2A
CCDC6
CEBPB
CHD3
CHD8
CREBBP
CREM
CRTC1
CRTC2
DNMT3L
DYRK1A
EDF1
ERG28
FHL5
GLI2
GSK3A
GSK3B
GTF2A1
GTF2F2
HIPK3
HIVEP1
HNF1B
HPS6
KAT5
KCNIP3
KIAA2026
MAPK14
MAPKAPK2
MTF2
NR3C1
PDX1
PIAS1
PIAS2
POGZ
POU2F1
PPP1CA
PRKACA
PRKG1
RAB1A
RBBP4
RECQL5
RFX3
RGS13
RNF111
RNF4
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KA5
SGK1
SMARCA4
SMARCA5
SMCO1
SOX9
SRA1
SREBF2
SRF
SUZ12
THRA
TOX4
TRIM22
TSSK4
UBE2I
VIM
YY1
ZHX1
ZMYM2
ZNF35
ZNF436
ZNF451
ZNF92
86 interacting genes:
ARHGEF11
ARHGEF12
ATXN3
BAD
CARHSP1
CCT4
CDKN1B
CEBPB
CFL1
CREB1
CREBBP
DDAH2
DEPTOR
DLC1
DLG4
EEF1D
EEF2K
ERBIN
ESR1
ETV1
FGFR1
FOS
GBP2
GMFB
GOPC
GORASP1
GORASP2
GRB2
GRID2IP
GSK3B
HTRA1
L1CAM
LIMK2
LNX1
MAGI1
MAGI2
MAGI3
MAPK1
MAPK3
MAPT
MAST1
MAST2
METTL1
MITF
MPP1
MTOR
MXD1
NFKBIA
NR4A1
NR4A2
NR4A3
PARD3B
PDCD4
PDPK1
PDZD7
PDZK1
PDZRN3
PDZRN4
PHAX
POLDIP3
PPM1G
PPP1R3A
PPP1R9A
PTPN3
RPTOR
SHANK3
SHROOM2
SLC9A3R2
SNTA1
SNTB1
SNTG2
SNX27
SRF
SRSF5
SYK
SYNJ2BP
TAMALIN
TOB2
TP53
TSC2
TTK
UBE2T
VCP
WHRN
YBX1
YWHAB
Entrez ID
1385
6195
HPRD ID
00442
03402
Ensembl ID
ENSG00000118260
ENSG00000117676
Uniprot IDs
B7Z5C6
P16220
Q53X93
Q5U0J5
Q15418
PDB IDs
2LXT
5ZK1
5ZKO
2WNT
2Z7Q
2Z7R
2Z7S
3RNY
3TEI
4H3P
4NIF
5CSF
5CSI
5CSJ
5CSN
5N7D
5N7F
5N7G
5V61
5V62
6TWY
Enriched GO Terms of Interacting Partners
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