PRF1 and GZMB

Data Source:
HPRD (in vivo)

		PRF1	GZMB
Description		perforin 1	granzyme B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane Integral Component Of Membrane Endosome Lumen Cytolytic Granule	Immunological Synapse Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Calcium Ion Binding Protein Binding Wide Pore Channel Activity Identical Protein Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Immunological Synapse Formation T Cell Mediated Cytotoxicity Defense Response To Tumor Cell Immune Response To Tumor Cell Apoptotic Process Cellular Defense Response Cytolysis Protein Homooligomerization Defense Response To Virus Positive Regulation Of Killing Of Cells Of Other Organism Transmembrane Transport	Apoptotic Process Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways			NOTCH2 intracellular domain regulates transcription Activation, myristolyation of BID and translocation to mitochondria
Drugs
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Multiple keratinocyte cancers ( 28081215) Obesity (extreme) ( 19553259)	Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)
Interacting Genes		8 interacting genes: CALR CYSRT1 DDX24 GZMB KRT31 NBPF19 NOTCH2NLA TRIM54	26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		5551	3002
HPRD ID		01362	00476
Ensembl ID		ENSG00000180644	ENSG00000100453
Uniprot IDs		P14222	J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs			1FQ3 1IAU
Enriched GO Terms of Interacting Partners?
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