PPP3CB and CABIN1

Data Source:
HPRD (two hybrid, in vivo)

		PPP3CB	CABIN1
Description		protein phosphatase 3 catalytic subunit beta	calcineurin binding protein 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Z Disc T-tubule Glutamatergic Synapse	Nucleus Nucleoplasm Cytosol Aggresome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Protein Dimerization Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Phosphatase Inhibitor Activity Nucleosome Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Lymphangiogenesis Protein Phosphorylation Protein Dephosphorylation Signal Transduction Wnt Signaling Pathway, Calcium Modulating Pathway Heart Development Learning Memory Dephosphorylation Calcium-ion Regulated Exocytosis T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Axon Extension Regulation Of Insulin Secretion Calcineurin-mediated Signaling Regulation Of Synaptic Vesicle Endocytosis	DNA Replication-independent Nucleosome Assembly Cell Surface Receptor Signaling Pathway Negative Regulation Of Phosphoprotein Phosphatase Activity
Pathways		DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation ROBO receptors bind AKAP5	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Amyotrophic lateral sclerosis ( 23624525) Coronary artery disease ( 29212778) S-phenylmercapturic acid levels in smokers ( 26959369) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		18 interacting genes: AATK CABIN1 EGFR FBXL17 IRAK1 IRF2 JUN LMTK2 MARCHF7 MYOZ2 MYOZ3 NFATC2 PTK7 ROR2 SLC8A1 SLC8A2 SLC8A3 SOCS3	12 interacting genes: AMPH BORCS8-MEF2B CALM1 CAMK4 DNM1 GRM1 MEF2B MEF2D PPP3CA PPP3CB PPP3CC YWHAQ
Entrez ID		5532	23523
HPRD ID		00235	10369
Ensembl ID		ENSG00000107758	ENSG00000099991
Uniprot IDs		B7Z781 P16298	A0A024R1E5 A0A087WWW8 Q9Y6J0
PDB IDs		4OR9 4ORA 4ORC	1N6J
Enriched GO Terms of Interacting Partners?
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